探索真核生物中的 RNA 引导的 DNA 剪刀：Fanzors 是 CRISPR-Cas12s 的对应物吗？
Exploring RNA-guided DNA scissors in eukaryotes: Are Fanzors counterparts of CRISPR-Cas12s?
机构信息
Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
出版信息
Cell. 2024 Sep 19;187(19):5220-5222. doi: 10.1016/j.cell.2024.08.022.
Fanzors are recently characterized RNA-guided DNA endonucleases found in eukaryotic organisms. In this issue of Cell, Xu, Saito et al. reveal the structural diversity of Fanzors and identify key features shared with TnpB and Cas12 proteins, providing a comprehensive perspective on their molecular function and evolution.
Fanzors 是最近在真核生物中发现的 RNA 指导的 DNA 内切酶。在本期《细胞》中，Xu、Saito 等人揭示了 Fanzors 的结构多样性，并确定了与 TnpB 和 Cas12 蛋白共享的关键特征，为其分子功能和进化提供了全面的视角。
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