Universidad de Castilla - La Mancha, Health and Social Research Center, Cuenca, Spain; Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Talca 7500912, Chile.
Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid 28029, Spain; ELIKOS Group, Institute for Sustainability and Food Chain Innovation (IS-FOOD), Department of Health Sciences, Public University of Navarre, Pamplona 31006, Spain.
Ageing Res Rev. 2024 Nov;101:102501. doi: 10.1016/j.arr.2024.102501. Epub 2024 Sep 18.
Higher levels of pulse wave velocity (PWV) have been related with the presence of small vessel disease that could damage the brain, in which white matter hyperintensities (WMH) could be presented as consequence. This meta-analysis aims to examine the cross-sectional and longitudinal associations between PWV and the presence of WMH among older adults.
We searched PubMed, Scopus, and WOS until June 2024. Pooled Odds Ratio (p-OR) were estimated for the cross-sectional and longitudinal associations between PWV and WMH. In addition, we explored whether this associations could be modified by type of PWV measurement and study and sample characteristics.
The p-OR between PWV and WMH was 1.16 (95 % CI, 1.10-1.22) for the cross-sectional and 1.07 (95 %, 1.00-1.15) for the longitudinal association. Similar figures were found by type of PWV measurement and no one of the explored characteristics modified this associations.
This meta-analysis revealed that the presence in and the long-term development of WMHs among older adults are more likely among those with elevated PWV.
脉搏波速度 (PWV) 水平升高与小血管疾病有关，小血管疾病可能会损害大脑，而脑白质高信号 (WMH) 可能是其后果。本荟萃分析旨在检查 PWV 与老年人 WMH 之间的横断面和纵向关联。
我们检索了 PubMed、Scopus 和 WOS，截至 2024 年 6 月。对 PWV 和 WMH 之间的横断面和纵向关联进行了汇总优势比 (p-OR) 估计。此外，我们还探讨了这些关联是否可以通过 PWV 测量类型和研究及样本特征进行修饰。
PWV 与 WMH 之间的横断面 p-OR 为 1.16（95%CI，1.10-1.22），纵向 p-OR 为 1.07（95%CI，1.00-1.15）。通过 PWV 测量类型发现了类似的数值，且未发现任何探索性特征修饰了这些关联。
本荟萃分析表明，在老年人中，PWV 升高与 WMH 的存在及其长期发展之间存在更强的相关性。
