Ma Enguang, Yi Jianing, Song Yekai, Li Hui, Geng Longlong, Zhang Chenkang, Hu Hui, Fu Zhinan, Zhu Baoyong, Guo Xuhong
Shandong Provincial Key Laboratory of Monocrystalline Silicon Semiconductor Materials and Technology, College of Chemistry and Chemical Engineering, Dezhou University, Dezhou 253023, China.
State Key Laboratory of Chemical Engineering, School of Chemical Engineering, East China University of Science and Technology, 200237 Shanghai, China.
Int J Biol Macromol. 2024 Nov;280(Pt 2):135781. doi: 10.1016/j.ijbiomac.2024.135781. Epub 2024 Sep 18.
Pesticides are vital for ensuring crop protection and stable yields, but their low efficiency and eco-unfriendly carriers raise environmental concerns. In this study, abamectin nanopesticides were designed and fabricated using natural polysaccharides [gum arabic (GA)] and a co-stabiliser via flash nanoprecipitation (FNP) method to reduce the size of nanopesticides and enhance their foliar affinity and deposition. Various co-stabilisers were innovatively introduced into the FNP process; the synergy between GA and the co-stabiliser significantly reduced the particle size (111.5 nm), narrowed the size distribution (polydispersity index = 0.078), and enhanced the stability and release performance of the nanopesticides. Importantly, the downsized nanopesticides effectively improved retention on leaf surfaces, reducing pesticide loss. In addition, because of the excellent control capability of the FNP method, the particle size of the nanopesticides could be flexibly adjusted by modifying the flow-based process parameters. Nanopesticides with small sizes demonstrated good control efficacy against Tetranychus urticae, comparable to those of commercial emulsion in water formulations. This study provides an effective approach for enhancing the utilisation efficiency of pesticide droplets by reducing particle size to ensure sustainable agriculture.
农药对于确保作物保护和稳定产量至关重要，但其效率低下且载体不环保引发了环境问题。在本研究中，通过快速纳米沉淀（FNP）法，使用天然多糖[阿拉伯胶（GA）]和一种共稳定剂设计并制备了阿维菌素纳米农药，以减小纳米农药的尺寸并增强其叶面亲和力和沉积。将各种共稳定剂创新性地引入FNP过程；GA与共稳定剂之间的协同作用显著减小了粒径（111.5纳米），缩小了粒径分布（多分散指数 = 0.078），并增强了纳米农药的稳定性和释放性能。重要的是，尺寸减小的纳米农药有效提高了在叶面上的滞留率，减少了农药损失。此外，由于FNP方法具有出色的控制能力，通过修改基于流动的工艺参数可以灵活调整纳米农药的粒径。小尺寸的纳米农药对二斑叶螨显示出良好的防治效果，与市售水乳剂相当。本研究提供了一种通过减小粒径来提高农药液滴利用效率的有效方法，以确保可持续农业。
