Renal Physiopathology Laboratory, Department of Nephrology, Instituto de Investigación Sanitaria Gregorio Marañón, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Department of Physiology, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain; RICORS2040, Madrid, Spain.
Renal Physiopathology Laboratory, Department of Nephrology, Instituto de Investigación Sanitaria Gregorio Marañón, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Department of Physiology, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain; RICORS2040, Madrid, Spain.
Kidney Int. 2024 Oct;106(4):560-562. doi: 10.1016/j.kint.2024.07.024.
Acute kidney injury is a devasting clinical syndrome resulting from multiple causes, characterized by an abrupt deterioration of kidney function for which there is no pharmacologic treatment. Cilastatin has demonstrated direct nephroprotective effects in acute kidney injury and now is shown to be effective to specifically target therapeutically loaded nanoparticles to the proximal tubule to treat acute kidney injury.
急性肾损伤是一种由多种原因引起的严重临床综合征，其特征为肾功能突然恶化，目前尚无药物治疗方法。西司他汀已证明在急性肾损伤中有直接的肾脏保护作用，现在已被证明可有效地将治疗性负载的纳米颗粒靶向到近端肾小管，从而治疗急性肾损伤。
