Wang Xudong, Zhang Shaolong, Xue Dixuan, Neculai Dante, Zhang Jin
Liangzhu Laboratory, Zhejiang University, Hangzhou, 311121, China; Center for Stem Cell and Regenerative Medicine, Department of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, China.
Liangzhu Laboratory, Zhejiang University, Hangzhou, 311121, China.
Trends Endocrinol Metab. 2024 Sep 19. doi: 10.1016/j.tem.2024.08.009.
Cancer presents a significant global public health challenge. Within the tumor microenvironment (TME), macrophages are the most abundant immune cell population. Tumor-associated macrophages (TAMs) undergo metabolic reprogramming through influence of the TME; thus, by manipulating key metabolic pathways such as glucose, lipid, or amino acid metabolism, it may be possible to shift TAMs towards an antitumor state, enhancing the immune response against tumors. Here, we highlight the metabolic reprogramming of macrophages as a potential approach for cancer immunotherapy. We explore the major pathways involved in the metabolic reprogramming of TAMs and offer new and valuable insights on the current technologies utilized for TAM reprogramming, including genome editing, antibodies, small molecules, nanoparticles and other in situ editing strategies.
癌症是一项重大的全球公共卫生挑战。在肿瘤微环境（TME）中，巨噬细胞是最丰富的免疫细胞群体。肿瘤相关巨噬细胞（TAM）通过TME的影响进行代谢重编程；因此，通过操纵关键代谢途径，如葡萄糖、脂质或氨基酸代谢，有可能使TAM转向抗肿瘤状态，增强针对肿瘤的免疫反应。在此，我们强调巨噬细胞的代谢重编程作为癌症免疫治疗的一种潜在方法。我们探讨了TAM代谢重编程所涉及的主要途径，并对目前用于TAM重编程的技术，包括基因组编辑、抗体、小分子、纳米颗粒和其他原位编辑策略提供了新的有价值的见解。
