College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, 410128, China.
Guangdong Chuangzhan Bona Agricultural Technology Co., Ltd, Guangning, 526339, China.
BMC Vet Res. 2024 Sep 20;20(1):422. doi: 10.1186/s12917-024-04133-5.
To assess the effects of inactivated Lactobacillus rhamnosus (ILR) on growth performance, serum biochemical indices, colonic microbiota, and metabolomics in weaned piglets, 120 piglets were randomly divided into five groups. Samples in the control group were fed a basal diet, while the experimental ILR1, ILR2, ILR3, and ILR4 groups were fed basal diets supplemented with 0.1%, 0.2%, 0.3%, and 0.4% ILR, respectively. The prefeeding period lasted for 5 days and was followed by a formal period of 28 days.
Compared to the control, the average daily gain increased by 4.38%, 7.98%, 19.32%, and 18.80% for ILR1, ILR2, ILR3, and ILR4, respectively, and the ratio of feed to gain decreased by 0.63%, 3.80%, 12.66%, and 10.76%, respectively. Serum IgA, IgG, IgM, total antioxidant capacity, and glutathione peroxidase levels increased significantly in weaned piglets in the treatment groups. Addition of 0.3% ILR significantly increased the Shannon and Simpson indices of the colonic microbiota in weaned piglets and altered the microbiota composition. Changes in metabolic profiles were observed and were primarily related to the urea cycle, amino acid metabolism, and lipid metabolism.
ILR improved growth performance and serum immunological and biochemical indices and optimized the colonic microbiota structure and metabolism of weaned piglets.
为了评估灭活鼠李糖乳杆菌（ILR）对断奶仔猪生长性能、血清生化指标、结肠微生物群和代谢组学的影响，将 120 头仔猪随机分为五组。对照组仔猪饲喂基础日粮，而实验组的 ILR1、ILR2、ILR3 和 ILR4 组则在基础日粮中添加 0.1%、0.2%、0.3%和 0.4%的 ILR。预饲期持续 5 天，然后进行为期 28 天的正式试验期。
与对照组相比，ILR1、ILR2、ILR3 和 ILR4 组仔猪的平均日增重分别提高了 4.38%、7.98%、19.32%和 18.80%，料肉比分别降低了 0.63%、3.80%、12.66%和 10.76%。处理组断奶仔猪血清 IgA、IgG、IgM、总抗氧化能力和谷胱甘肽过氧化物酶水平显著升高。添加 0.3%的 ILR 显著提高了断奶仔猪结肠微生物群的 Shannon 和 Simpson 指数，并改变了微生物群组成。观察到代谢谱的变化，主要与尿素循环、氨基酸代谢和脂质代谢有关。
ILR 改善了断奶仔猪的生长性能以及血清免疫和生化指标，优化了结肠微生物群结构和代谢。
