Graduate Medical Education Research Department, Northeast Georgia Medical Center, Gainesville, GA, USA.
Department of Emergency Medicine, Northeast Georgia Medical Center, Gainesville, GA, USA.
Am J Case Rep. 2024 Sep 21;25:e944273. doi: 10.12659/AJCR.944273.
BACKGROUND Reversible cerebral vasoconstriction syndrome (RCVS) is a rare disease that is classified as a condition of diffuse cerebral artery constriction. RCVS can be complicated with transient neurological deficits, seizures, ischemic strokes, and hemorrhagic strokes. A thunder-clap headache, described as being the worst headache a patient can experience, is the predominant symptom in RCVS, which contributes to why RCVS is underdiagnosed as an ischemic stroke or migraine. CASE REPORT In this case study, we present a healthy 34-year-old Black woman who presented to the Emergency Department 3 times over a period of 4 days with concerns of severe headaches. In her first Emergency Department visit, she had a normal computed tomography scan of the brain. Her third Emergency Department visit resulted in hospitalization due to seizures, and a computed tomography brain scan done then showed acute intracranial hemorrhaging. The patient ultimately received a diagnosis of RCVS during her hospitalization. CONCLUSIONS RCVS is the most notable mimicker of other similar-presenting vasculopathies, such as primary angiitis of the central nervous system and posterior reversible encephalopathy syndrome. It is important to note that thunder-clap headache, as well as complications such as intracranial hemorrhaging and seizures, can arise not just from other diseases but from RCVS as well; hence, an early diagnosis is critical to avoid complications, especially if initial imaging is negative.
可逆性脑血管收缩综合征(RCVS)是一种罕见的疾病,归类为弥漫性脑血管收缩状态。RCVS 可并发短暂性神经功能缺损、癫痫发作、缺血性卒中和出血性卒中。RCVS 的主要症状是霹雳样头痛(thunder-clap headache),这种头痛被描述为患者所能经历的最严重的头痛,这也是 RCVS 被误诊为缺血性卒中和偏头痛的原因之一。
在本病例研究中,我们介绍了一位健康的 34 岁黑人女性,她在 4 天的时间里 3 次因严重头痛到急诊科就诊。她第一次到急诊科就诊时,脑部计算机断层扫描(CT)正常。她第三次到急诊科就诊时因癫痫发作住院,随后进行的脑部 CT 扫描显示急性颅内出血。患者最终在住院期间被诊断为 RCVS。
RCVS 是其他类似血管病变(如中枢神经系统原发性血管炎和可逆性后部脑病综合征)最显著的类似疾病。需要注意的是,霹雳样头痛以及颅内出血和癫痫等并发症不仅可能由其他疾病引起,也可能由 RCVS 引起;因此,早期诊断对于避免并发症至关重要,尤其是在初始影像学检查为阴性时。