Mercy One Waterloo Medical Center, Waterloo, 50702, Iowa, USA.
Detroit Medical Center, Hutzel Women's Hospital, Detroit, 48201, Michigan, USA.
JPEN J Parenter Enteral Nutr. 2024 Nov;48(8):949-955. doi: 10.1002/jpen.2689. Epub 2024 Sep 21.
There is limited evidence on benefits of SMOF lipids (mixed fatty acid emulsion of 30% soybean oil, 30% medium chain triglycerides, 25% olive oil, and 15% fish oil) in reducing parenteral nutrition-associated cholestasis in extremely low birth weight infants, compared with soybean oil-based Intralipid.
To compare incidence of parenteral nutrition-associated cholestasis in preterm infants who received Intralipid vs SMOF lipid.
We conducted a retrospective study on infants with birth weight <1000 g, admitted between January 2013 to December 2022, who received parenteral nutrition for >14 days and divided them into two groups based on lipid emulsion received (Intralipid, n = 187, SMOF, n = 127). Primary outcome was incidence of parenteral nutrition-associated cholestasis, defined as direct bilirubin ≥2 mg/dl.
Baseline characteristics did not differ between the two groups. No significant difference was noted in parenteral nutrition-associated cholestasis between the two groups on logistic regression, (adjusted odds ratio: 0.71, 95% confidence interval 0.35-1.42, P value 0.33) after adjusting for gestational age, parenteral nutrition days, lipid days, and late-onset sepsis.
There was no difference in the rates of parenteral nutrition-associated cholestasis between preterm infants administered SMOF lipids and those given Intralipid.
与大豆油为基础的 Intralipid 相比，SMOF 脂质（30%大豆油、30%中链甘油三酯、25%橄榄油和 15%鱼油的混合脂肪酸乳剂）在降低极低出生体重儿肠外营养相关胆汁淤积方面的益处证据有限。
比较接受 Intralipid 与 SMOF 脂质的早产儿肠外营养相关胆汁淤积的发生率。
我们对 2013 年 1 月至 2022 年 12 月期间出生体重<1000g、接受肠外营养>14 天的婴儿进行了一项回顾性研究，并根据所接受的脂肪乳剂将其分为两组（Intralipid，n=187，SMOF，n=127）。主要结局是肠外营养相关胆汁淤积的发生率，定义为直接胆红素≥2mg/dl。
两组间的基线特征无差异。在调整了胎龄、肠外营养天数、脂肪乳剂天数和晚发性败血症后，两组间肠外营养相关胆汁淤积的 logistic 回归无显著差异（调整后比值比：0.71，95%置信区间 0.35-1.42，P 值 0.33）。
给予 SMOF 脂质和 Intralipid 的早产儿肠外营养相关胆汁淤积的发生率无差异。
