Florida International University Robert Stempel College of Public Health and Social Work, Department of Health Promotion and Disease Prevention, Miami, FL, USA.
Center for Innovations in Quality, Effectiveness, and Safety, Michael E. DeBakey VA Medical Center, Houston, TX 77021, USA.
Ann Behav Med. 2024 Nov 16;58(12):779-788. doi: 10.1093/abm/kaae055.
There is clear evidence that loneliness and social isolation have profound health consequences. Documenting the associations of loneliness and social isolation with inflammatory bowel disease (IBD) symptoms, disease severity, and treatment outcomes could meaningfully improve health and quality of life in patients with IBD.
The purpose of this narrative review was to synthesize the empirical evidence on the associations of loneliness and social isolation with IBD symptoms, disease severity, and treatment outcomes.
Articles were identified through systematic database searches. Quantitative studies that enrolled patients with IBD were included if they examined one of the following outcomes: (a) loneliness or social isolation or (b) IBD-related symptoms, disease severity, or treatment outcomes.
We identified 1,816 articles after removing duplicates. Of the 18 studies that met the inclusion criteria, 15 were cross-sectional and 3 were longitudinal. Overall, studies found that loneliness was associated with greater disease activity, functional gastrointestinal symptoms, IBD illness stigma, depressive symptoms, daily IBD symptom burden, reduced resilience, and poorer quality of life. Social isolation was associated with higher prevalence of IBD hospitalizations, premature mortality, and depression.
Findings suggest that loneliness and social isolation are associated with poorer health and quality of life in patients with IBD. Prospective cohort studies examining the biobehavioral mechanisms accounting for the associations of loneliness and social isolation with IBD-related outcomes are needed to guide the development of psychological interventions for individuals living with IBD.
有明确的证据表明，孤独和社会隔离对健康有深远的影响。记录孤独和社会隔离与炎症性肠病（IBD）症状、疾病严重程度和治疗结果的关联，可以显著改善 IBD 患者的健康和生活质量。
本叙述性综述的目的是综合孤独和社会隔离与 IBD 症状、疾病严重程度和治疗结果相关的实证证据。
通过系统的数据库搜索来识别文章。如果研究考察了以下结果之一，则纳入了纳入了定量研究：（a）孤独或社会隔离或（b）与 IBD 相关的症状、疾病严重程度或治疗结果。
我们在去除重复项后确定了 1816 篇文章。在符合纳入标准的 18 项研究中，有 15 项是横断面研究，3 项是纵向研究。总的来说，研究发现孤独与更高的疾病活动度、功能性胃肠道症状、IBD 疾病耻辱感、抑郁症状、每日 IBD 症状负担、降低的适应力和较差的生活质量相关。社会隔离与更高的 IBD 住院率、过早死亡率和抑郁相关。
研究结果表明，孤独和社会隔离与 IBD 患者的健康和生活质量较差有关。需要前瞻性队列研究来检查孤独和社会隔离与 IBD 相关结果相关的生物行为机制，以指导针对患有 IBD 的个体的心理干预措施的制定。
