Department of Biomedical Science and Technology, Graduate School, Kyung Hee University, Seoul 02447, South Korea.
KHU-KIST Department of Converging Science and Technology, Graduate School, Kyung Hee University, Seoul 02447, South Korea.
Arch Gerontol Geriatr. 2025 Jan;128:105637. doi: 10.1016/j.archger.2024.105637. Epub 2024 Sep 11.
Frailty is associated with reduced intrinsic capacity (IC). However, studies evaluating longitudinal transitions between IC and frailty are limited. We conducted longitudinal analyses to investigate the association between intrinsic capacity (IC) and frailty transitions among community-dwelling older adults in Korea.
A total of 2,345 older adults who completed baseline and two-year follow-up surveys were selected from the Korean Frailty and Aging Cohort Study. IC was measured in five domains: locomotion, vitality, cognition, psychology, and sensory function. Frailty was defined using the Fried frailty phenotype. Transitions in IC and frailty were assessed. Logistic regression analysis was used to analyze the association between baseline IC, IC transitions, and frailty transitions.
During the two-year follow-up, 17.8 % of participants improved, 20.4 % worsened, and 61.8 % maintained the same frailty status. Low IC (odds ratio [OR]=1.93; 95 % confidence interval [CI]=1.42-2.61) significantly predicted remaining frail or worsening frailty. Worsened IC increased the risk of remaining frail or worsening frailty, whereas improved IC decreased this risk. Among the IC domains, the onset of new locomotion (OR=3.33; 95 % CI=2.39-4.64), vitality (OR=2.12; 95 % CI=1.55-2.91), and psychological (OR=3.61; 95 % CI=2.64-4.92) impairment predicted remaining frail or worsening frailty.
Low and worsened IC were associated with an increased risk of remaining frail or worsening frailty over two years. These findings indicate that changes in IC can predict frailty transitions, thereby emphasizing the importance of enhancing IC in preventing frailty progression.
衰弱与内在能力（IC）降低有关。然而，评估 IC 与虚弱之间纵向转变的研究有限。我们进行了纵向分析，以研究韩国社区居住的老年人中内在能力（IC）与虚弱转变之间的关系。
从韩国虚弱和衰老队列研究中选择了总共 2345 名完成基线和两年随访调查的老年人。在五个领域测量 IC：运动、活力、认知、心理和感觉功能。使用 Fried 虚弱表型定义虚弱。评估 IC 和虚弱的转变。使用逻辑回归分析来分析基线 IC、IC 转变和虚弱转变之间的关系。
在两年的随访期间，17.8%的参与者改善，20.4%恶化，61.8%保持相同的虚弱状态。低 IC（比值比 [OR]=1.93；95%置信区间 [CI]=1.42-2.61）显著预测持续虚弱或恶化虚弱。恶化的 IC 增加了持续虚弱或恶化虚弱的风险，而改善的 IC 降低了这种风险。在 IC 领域中，新出现的运动（OR=3.33；95%CI=2.39-4.64）、活力（OR=2.12；95%CI=1.55-2.91）和心理（OR=3.61；95%CI=2.64-4.92）障碍的发生预测了持续虚弱或恶化虚弱。
低和恶化的 IC 与两年内持续虚弱或恶化虚弱的风险增加相关。这些发现表明 IC 的变化可以预测虚弱转变，从而强调增强 IC 预防虚弱进展的重要性。
