Immunometabolism, Department of Nutrition, Nursing School, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Interdisciplinary Laboratory of Medical Investigation, Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Clin Nutr. 2024 Oct;43(10):2438-2447. doi: 10.1016/j.clnu.2024.09.029. Epub 2024 Sep 17.
BACKGROUND & AIMS: Obesity is associated with chronic low-grade inflammation, and adipose tissue inflammation is required for fatty tissue remodeling. Interestingly, immunosuppressed patients, as liver transplant recipients, often experience excessive weight gain. We investigated how liver recipients' inflammatory response affects body weight loss induced by dietary treatment.
Overweight liver recipients were paired with non-transplanted subjects to compare their peripheral immune profiles.
Transplanted patients had similar profiles of peripheral blood mononuclear cells compared to controls but lower CD8CD56CD16NK cells and higher B lymphocytes. Patients showed lower serum concentrations of IFN-γ, TNF, IL-4, IL-2, and IL-10 and lower inflammatory responsiveness of peripheral blood mononuclear cells under inflammatory stimuli. Liver recipients paired with non-transplanted subjects followed a weight loss dietary plan for 6 months to verify body composition changes. After 3 and 6 months of nutritional follow-up, the control group lost more body weight than the liver recipient group. The control group decreased fat mass and waist circumference, which was not observed in transplanted patients.
Therefore, liver recipients under immunosuppressant treatment responded less to different inflammatory stimuli. This impaired inflammatory milieu might be implicated in the lack of response to weight loss dietary intervention. Inflammation may be essential to trigger the weight loss induced by dietary prescription.
ClinicalTrials.gov identification number: NCT03103984.
肥胖与慢性低度炎症有关，脂肪组织炎症是脂肪组织重塑所必需的。有趣的是，接受器官移植的免疫抑制患者，如肝移植受者，往往会出现体重过度增加。我们研究了肝移植受者的炎症反应如何影响饮食治疗引起的体重减轻。
超重的肝移植受者与未接受移植的患者进行配对，以比较他们的外周免疫特征。
与对照组相比，移植患者的外周血单个核细胞具有相似的特征，但 CD8CD56CD16NK 细胞较少，B 淋巴细胞较多。患者的血清 IFN-γ、TNF、IL-4、IL-2 和 IL-10 浓度较低，在外周血单个核细胞受到炎症刺激时的炎症反应性较低。与未接受移植的患者配对的肝移植受者遵循了为期 6 个月的减肥饮食计划，以验证身体成分的变化。经过 3 个月和 6 个月的营养随访，对照组比肝移植组体重减轻更多。对照组减少了脂肪量和腰围，而移植患者则没有观察到这一现象。
因此，接受免疫抑制剂治疗的肝移植受者对不同的炎症刺激反应较低。这种受损的炎症环境可能与对减肥饮食干预的反应不足有关。炎症可能对饮食处方引起的体重减轻至关重要。
ClinicalTrials.gov 注册号：NCT03103984。
