Capital Medical University School of Nursing, 10 Xitoutiao, You 'anmen Wai Street, Fengtai District, Beijing, 100069, China.
Xuanwu Hospital Capital Medical University, 45 Changchun Street, Xicheng District, Beijing, 100053, China.
Complement Ther Clin Pract. 2024 Nov;57:101906. doi: 10.1016/j.ctcp.2024.101906. Epub 2024 Sep 11.
The use of various adjunctive phototherapies for diabetic foot ulcers (DFUs) makes it difficult to fully understand their roles in current laser-based review studies. Red and infrared light have significant advantages for wound healing. To evaluate the impact of red and infrared light on the healing of DFUs and provide evidence-based recommendations for future clinical adjunctive treatments of DFUs.
Multiple databases, including PubMed, EMBASE, Cochrane Library, Web of Science, CINAHL, PEDro, CNKI, CBM, Wanfang, and VIP, were systematically searched for articles published until November 2023. The focus of the search was to identify randomised controlled trials that investigated the effects of red and infrared light on the treatment of DFUs. Data extraction, literature screening, and methodological quality assessment were conducted independently by two researchers. A meta-analysis was performed using RevMan5.4 and STATA16.0 software.
A total of 28 studies, involving 1471 patients, were included. The meta-analysis showed that groups treated with red and infrared light had a significantly higher ulcer healing rate [risk ratio (RR) = 1.93, 95 % confidence interval (CI) (1.63, 2.28), P < 0.00001], shorter ulcer healing time [mean difference (MD) = 18.52, 95 % CI (8.58, 28.47), P < 0.00001], increased peak blood flow velocity in the dorsalis pedis artery [mean difference (MD) = 6.54, 95 % CI (4.01,9.08)], P < 0.00001), and reduced wound pain score [mean difference (MD) = -4.33, 95 % CI (-4.94, -3.71)], P < 0.00001) compared to the control group. However, there was no statistically significant difference in the incidence of adverse events [odds ratio (OR) = 0.32, 95 % CI (0.09, 1.17), P = 0.08] between the two methods.
The use of red and infrared light as an adjunctive treatment for DFUs is more beneficial than conventional wound care. However, due to limitations in the quality and sample size of the included studies, further high-quality research is needed to validate these conclusions.
糖尿病足溃疡（DFUs）的各种辅助光疗方法使得很难全面了解它们在当前基于激光的综述研究中的作用。红光是治疗伤口的一种新型手段，在伤口愈合方面具有显著优势。评估红、远红光治疗 DFU 的效果，为今后 DFU 的临床辅助治疗提供循证推荐。
系统检索 PubMed、EMBASE、Cochrane 图书馆、Web of Science、CINAHL、PEDro、CNKI、CBM、万方和维普等多个数据库，截至 2023 年 11 月，检索文献以确定关于红、远红光治疗 DFU 的随机对照试验。由两名研究者独立进行数据提取、文献筛选和方法学质量评估。使用 RevMan5.4 和 STATA16.0 软件进行荟萃分析。
共纳入 28 项研究，涉及 1471 例患者。荟萃分析显示，红、远红光治疗组溃疡愈合率显著较高[风险比（RR）=1.93，95%置信区间（CI）（1.63，2.28），P<0.00001]，溃疡愈合时间明显缩短[均数差（MD）=18.52，95%CI（8.58，28.47），P<0.00001]，足背动脉峰值血流速度增加[MD=6.54，95%CI（4.01，9.08）]，P<0.00001），创面疼痛评分降低[MD=-4.33，95%CI（-4.94，-3.71）]，P<0.00001）。与对照组相比，两组不良事件发生率差异无统计学意义[比值比（OR）=0.32，95%CI（0.09，1.17），P=0.08]。
红、远红光作为 DFU 的辅助治疗方法比常规伤口护理更有益。但是，由于纳入研究的质量和样本量存在局限性，需要进一步的高质量研究来验证这些结论。
