Department of Neurosurgery, The University of Tokyo Hospital, Tokyo, Japan.
Department of Neurosurgery, The University of Tokyo Hospital, Tokyo, Japan; Department of Medical Information Engineering, Graduate School of Medicine, The University of Tokyo, Japan.
J Neuroradiol. 2024 Nov;51(6):101221. doi: 10.1016/j.neurad.2024.101221. Epub 2024 Sep 19.
Although arterial stiffness is known as a biomarker for cardiovascular events and stroke, there is limited information in the literature regarding the stiffness of intracranial aneurysms. In this study, we aim to assess the stiffness of intracranial aneurysms using 4D Flow MRI.
A total of 27 aneurysms in 25 patients with internal carotid artery aneurysms were included in this study. Using 4D Flow MRI, we measured the arterial pulse wave form during a cardiac cycle at planes proximal and distal to the target aneurysm. The damping of these waveforms through the aneurysm was defined as the aneurysm damping index (ADI) and compared to the contralateral side. We also investigated the clinical factors related to the ADI.
ADI assessment was successful in all cases. The average ADI was 1.18±0.28, which was significantly larger than 1.0 (P = 0.0027 [t-test]). The ADI on the aneurysm side was larger than on the contralateral side (1.19±0.30 vs 1.05±0.17, P = 0.029 [t-test]). On multivariate analysis, the use of beta-blockers (β=0.46, P = 0.015) and smoking history (β=-0.22, P = 0.024) showed a significant correlation with ADI.
We have proposed a novel method to observe arterial pulse wave dumping through intracranial aneurysm using 4D Flow MRI. The damping can be quantitatively observed, and the ADI has correlations with clinical factors such as antihypertensive drugs and smoking. Further studies should focus more on evaluating aneurysm stiffness and its clinical applications.
尽管动脉僵硬度被认为是心血管事件和中风的生物标志物，但关于颅内动脉瘤的僵硬度，文献中的信息有限。在本研究中，我们旨在使用 4D Flow MRI 评估颅内动脉瘤的僵硬度。
本研究共纳入 25 例颈内动脉动脉瘤患者的 27 个动脉瘤。使用 4D Flow MRI，我们在目标动脉瘤近端和远端平面测量了心动周期期间的动脉脉搏波形。通过动脉瘤阻尼这些波形的程度定义为动脉瘤阻尼指数（ADI），并与对侧进行比较。我们还研究了与 ADI 相关的临床因素。
所有病例的 ADI 评估均成功。平均 ADI 为 1.18±0.28，明显大于 1.0（P = 0.0027 [t 检验]）。动脉瘤侧的 ADI 大于对侧（1.19±0.30 与 1.05±0.17，P = 0.029 [t 检验]）。多变量分析显示，使用β受体阻滞剂（β=0.46，P = 0.015）和吸烟史（β=-0.22，P = 0.024）与 ADI 呈显著相关。
我们提出了一种使用 4D Flow MRI 观察颅内动脉瘤动脉脉搏波排空的新方法。可以对阻尼进行定量观察，ADI 与降压药物和吸烟等临床因素相关。进一步的研究应更侧重于评估动脉瘤的僵硬度及其临床应用。
