• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

从儿童期到老年期的认知表现以及多代际 Young Finns 研究中的代际相关性。

Cognitive performance from childhood to old age and intergenerational correlations in the multigenerational Young Finns Study.

机构信息

Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.

Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.

出版信息

J Neurol. 2024 Nov;271(11):7294-7308. doi: 10.1007/s00415-024-12693-7. Epub 2024 Sep 22.

DOI:10.1007/s00415-024-12693-7
PMID:39306829
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11561001/
Abstract

BACKGROUND

Cognitive performance changes during the lifespan, but the information is gathered from studies on separate age cohorts. Computerized neurocognitive testing enables efficient and similar assessments for all ages. We investigated (i) the effect of age at different stages of life and (ii) intergenerational correlations across cognitive domains in the multigenerational Young Finns Study.

METHODS

Participants in three familiarly related generations (n = 6486, aged 7-92 years) performed the Cambridge Neuropsychological Test Automated Battery (CANTAB). Overall cognitive performance and domains representing learning and memory, working memory, information processing, and reaction time were extracted by common principal component analysis from the cognitive data with several age groups. Linear models were used to study the association of age, sex, and education with overall cognitive performance and in the cognitive domains. Age-adjusted intergenerational correlations were calculated.

RESULTS

Learning and memory peaked earlier during the lifespan compared to working memory and information processing, and the rate of decline toward old age differed by domain. Weak intergenerational correlations existed between two consecutive generations but were nonsignificant between grandparents and grandchildren. There was no systematic sex-specific transmission in any cognitive domain.

CONCLUSION

This study describes the natural course of cognitive performance across the lifespan and proves that cognitive performance changes differently across cognitive domains with weak intergenerational transmission.

摘要

背景

认知表现会随着生命周期而变化，但这些信息是通过对不同年龄队列的研究收集的。计算机化神经认知测试可以为所有年龄段提供高效且相似的评估。我们研究了（i）在生命不同阶段的年龄效应，以及（ii）多代 Young Finns 研究中跨认知领域的代际相关性。

方法

三代具有亲缘关系的参与者（n=6486，年龄 7-92 岁）进行了剑桥神经心理测试自动化电池（CANTAB）测试。通过常见的主成分分析，从认知数据中提取出代表学习和记忆、工作记忆、信息处理和反应时间的整体认知表现和认知领域。线性模型用于研究年龄、性别和教育与整体认知表现和认知领域的关联。计算了年龄调整后的代际相关性。

结果

与工作记忆和信息处理相比，学习和记忆在生命周期中更早达到峰值，并且各领域的衰老速度不同。连续两代之间存在较弱的代际相关性，但祖父母和孙辈之间的相关性不显著。在任何认知领域都没有系统的性别特异性传递。

结论

本研究描述了认知表现随生命周期的自然变化过程，并证明认知表现随认知领域的不同而不同，代际传递较弱。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62cf/11561001/1c6c5015ca3d/415_2024_12693_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62cf/11561001/c4fc194fd21d/415_2024_12693_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62cf/11561001/2b3297b573cf/415_2024_12693_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62cf/11561001/601fe39e4dd7/415_2024_12693_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62cf/11561001/1c6c5015ca3d/415_2024_12693_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62cf/11561001/c4fc194fd21d/415_2024_12693_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62cf/11561001/2b3297b573cf/415_2024_12693_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62cf/11561001/601fe39e4dd7/415_2024_12693_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62cf/11561001/1c6c5015ca3d/415_2024_12693_Fig4_HTML.jpg

相似文献

1
Cognitive performance from childhood to old age and intergenerational correlations in the multigenerational Young Finns Study.从儿童期到老年期的认知表现以及多代际 Young Finns 研究中的代际相关性。
J Neurol. 2024 Nov;271(11):7294-7308. doi: 10.1007/s00415-024-12693-7. Epub 2024 Sep 22.
2
Change in cognitive performance during seven-year follow-up in midlife is associated with sex, age, and education - The Cardiovascular Risk in Young Finns Study.中年期七年随访期间认知表现的变化与性别、年龄和教育有关-芬兰年轻人心血管风险研究。
J Neurol. 2024 Aug;271(8):5165-5176. doi: 10.1007/s00415-024-12466-2. Epub 2024 Jun 2.
3
Cognitive performance in young adulthood and midlife: Relations with age, sex, and education-The Cardiovascular Risk in Young Finns Study.青年期和中年期的认知表现：与年龄、性别和教育的关系——芬兰青年人心血管风险研究
Neuropsychology. 2016 Jul;30(5):532-42. doi: 10.1037/neu0000239. Epub 2015 Nov 2.
4
Comparing Web-Based and Lab-Based Cognitive Assessment Using the Cambridge Neuropsychological Test Automated Battery: A Within-Subjects Counterbalanced Study.基于剑桥神经心理测试自动化电池的网络与实验室认知评估比较：一项被试内平衡研究。
J Med Internet Res. 2020 Aug 4;22(8):e16792. doi: 10.2196/16792.
5
Assessment of neuropsychological performance in Mexico City youth using the Cambridge Neuropsychological Test Automated Battery (CANTAB).使用剑桥神经心理学测试自动化电池（CANTAB）评估墨西哥城青年的神经心理学表现。
J Clin Exp Neuropsychol. 2019 Apr;41(3):246-256. doi: 10.1080/13803395.2018.1529229. Epub 2018 Oct 18.
6
Normative data from the CANTAB. I: development of executive function over the lifespan.剑桥神经心理测试自动化成套系统的常模数据。I：一生中执行功能的发展。
J Clin Exp Neuropsychol. 2003 Apr;25(2):242-54. doi: 10.1076/jcen.25.2.242.13639.
7
Influence of schooling and age on cognitive performance in healthy older adults.学校教育和年龄对健康老年人认知表现的影响。
Braz J Med Biol Res. 2017 Mar 23;50(4):e5892. doi: 10.1590/1414-431X20165892.
8
Factorial validity, measurement equivalence and cognitive performance of the Cambridge Neuropsychological Test Automated Battery (CANTAB) between patients with first-episode psychosis and healthy volunteers.首发精神病患者与健康志愿者之间剑桥神经心理测试自动成套系统（CANTAB）的效标效度、测量等效性及认知表现
Psychol Med. 2015 Jul;45(9):1919-29. doi: 10.1017/S0033291714003018. Epub 2014 Dec 29.
9
The subtleties of cognitive decline in multiple sclerosis: an exploratory study using hierarchichal cluster analysis of CANTAB results.多发性硬化症认知衰退的细微之处：一项使用对剑桥神经心理测试自动化成套系统（CANTAB）结果进行层次聚类分析的探索性研究。
BMC Neurol. 2018 Sep 10;18(1):140. doi: 10.1186/s12883-018-1141-1.
10
Physical Activity from Childhood to Adulthood and Cognitive Performance in Midlife.从儿童期到成年期的身体活动与中年认知表现。
Med Sci Sports Exerc. 2019 May;51(5):882-890. doi: 10.1249/MSS.0000000000001862.

本文引用的文献

1
Change in cognitive performance during seven-year follow-up in midlife is associated with sex, age, and education - The Cardiovascular Risk in Young Finns Study.中年期七年随访期间认知表现的变化与性别、年龄和教育有关-芬兰年轻人心血管风险研究。
J Neurol. 2024 Aug;271(8):5165-5176. doi: 10.1007/s00415-024-12466-2. Epub 2024 Jun 2.
2
The genetics of specific cognitive abilities.特定认知能力的遗传学
Intelligence. 2022 Nov-Dec;95:101689. doi: 10.1016/j.intell.2022.101689.
3
The intergenerational transmission of executive function: The mediating effect of parental harsh discipline.
执行功能的代际传递：父母严厉管教的中介作用。
Child Abuse Negl. 2023 Feb;136:106019. doi: 10.1016/j.chiabu.2022.106019. Epub 2023 Jan 4.
4
Cognitive Control Challenge Task Across the Lifespan.贯穿一生的认知控制挑战任务
Front Psychol. 2022 Feb 9;12:789816. doi: 10.3389/fpsyg.2021.789816. eCollection 2021.
5
Genetic influence on cognitive development between childhood and adulthood.童年至成年期遗传对认知发展的影响。
Mol Psychiatry. 2021 Feb;26(2):656-665. doi: 10.1038/s41380-018-0277-0. Epub 2018 Oct 19.
6
Cognitive genomics: Searching for the genetic roots of neuropsychological functioning.认知基因组学：探寻神经心理功能的遗传根源。
Neuropsychology. 2017 Nov;31(8):1003-1019. doi: 10.1037/neu0000412.
7
Linking ADHD to the Neural Circuitry of Attention.将注意力缺陷多动障碍与注意力神经回路相联系。
Trends Cogn Sci. 2017 Jun;21(6):474-488. doi: 10.1016/j.tics.2017.03.009. Epub 2017 May 5.
8
Changing relations among cognitive abilities across development: implications for measurement and research.认知能力在发展过程中的变化关系：对测量和研究的启示。
Clin Neuropsychol. 2017 Nov;31(8):1353-1374. doi: 10.1080/13854046.2017.1317034. Epub 2017 Apr 11.
9
The Computerized Neurocognitive Battery: Validation, aging effects, and heritability across cognitive domains.计算机化神经认知测试组合：认知领域的效度验证、衰老效应及遗传性
Neuropsychology. 2016 Jan;30(1):53-64. doi: 10.1037/neu0000248.
10
Cognitive performance in young adulthood and midlife: Relations with age, sex, and education-The Cardiovascular Risk in Young Finns Study.青年期和中年期的认知表现：与年龄、性别和教育的关系——芬兰青年人心血管风险研究
Neuropsychology. 2016 Jul;30(5):532-42. doi: 10.1037/neu0000239. Epub 2015 Nov 2.