Zielen S, Bender S W, Kreuz W, Posselt H G, Solem E, Scharrer I
J Pediatr Gastroenterol Nutr. 1985 Oct;4(5):730-4.
Twenty-eight patients (mean age 13.5 years) with proven Crohn's disease were examined for factor VIII coagulation activity (VIII:C), factor VIII-related antigen (VIII R:Ag), and factor VIII-related ristocetin cofactor activity (VIII R:RCF). The factor VIII coagulation proteins were correlated with disease activity index according to van Hees and were compared with inflammatory parameters such as erythrocyte sedimentation rate, c-reactive protein, and orosomucoid. Among the factor VIII proteins, factor VIII-related protein (VIII R:Ag) correlates best with van Hees disease activity index, orosomucoid, c-reactive protein, and erythrocyte sedimentation rate (p less than 0.001 for all parameters). Since acute phase proteins are produced by liver cells, whereas VIII R:Ag is synthesized by endothelial cells, we postulate that this coagulation factor is highly sensitive in reflecting the inflammatory process in the intestine.
对28例确诊为克罗恩病的患者（平均年龄13.5岁）进行了凝血因子VIII活性（VIII:C）、VIII因子相关抗原（VIII R:Ag）和VIII因子相关瑞斯托霉素辅因子活性（VIII R:RCF）检测。根据范赫斯标准，将凝血因子VIII相关蛋白与疾病活动指数进行关联，并与红细胞沉降率、C反应蛋白和类粘蛋白等炎症参数进行比较。在凝血因子VIII相关蛋白中，VIII因子相关抗原（VIII R:Ag）与范赫斯疾病活动指数、类粘蛋白、C反应蛋白和红细胞沉降率的相关性最佳（所有参数的p值均小于0.001）。由于急性期蛋白由肝细胞产生，而VIII R:Ag由内皮细胞合成，我们推测该凝血因子在反映肠道炎症过程方面高度敏感。
