Stockmeier C A, Larsen B R, Blask D E
J Neurosci Res. 1985;14(2):279-84. doi: 10.1002/jnr.490140213.
Convulsions from combined pinealectomy and parathyroidectomy were examined in rats treated as neonates with 6-hydroxydopamine (6-OHDA). Injection of 6-OHDA caused a significant reduction in the average latency to onset of clonic-tonic convulsions. Moreover, of the 6-OHDA-treated rats which convulsed, nearly half of them died during a seizure. In sham-pinealectomized rats, neonatal treatment with 6-OHDA reduced norepinephrine (NE) and increased dopamine levels in the forebrain while brainstem levels of NE were increased. Pretreatment with desmethylimipramine reversed the effects of 6-OHDA on convulsions and catecholamine levels. The results indicate that catecholamine lesions with 6-OHDA exacerbate convulsions from pinealectomy.
在新生期用6-羟基多巴胺（6-OHDA）处理的大鼠中，研究了松果体切除术和甲状旁腺切除术联合导致的惊厥。注射6-OHDA导致阵挛-强直惊厥发作的平均潜伏期显著缩短。此外，在发生惊厥的6-OHDA处理的大鼠中，近一半在惊厥期间死亡。在假松果体切除的大鼠中，新生期用6-OHDA处理可降低前脑中去甲肾上腺素（NE）水平并增加多巴胺水平，而脑干中的NE水平升高。用去甲丙咪嗪预处理可逆转6-OHDA对惊厥和儿茶酚胺水平的影响。结果表明，6-OHDA导致的儿茶酚胺损伤会加剧松果体切除引起的惊厥。
