Zhou J J, Li M S, Zhang Q, Yan T T, Wu D, Li Y X, Li J H, Yin Z D, Zheng H, An Z J
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Beijing 102206, China Immunization Program Center, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2024 Sep 10;45(9):1197-1203. doi: 10.3760/cma.j.cn112338-20240312-00117.
To understand the incidence trend of meningococcal meningitis from 1990 to 2023 and major pathogenic serogroups of () from 2006 to 2023 in China and the time trend of the incidence of meningococcal meningitis caused by main pathogenic serogroups, and provide reference for the prevention and control of meningococcal meningitis. The study used the data from "National Epidemic Data Compile" from 1990 to 2003 and the data from China Notifiable Infectious Disease Reporting System from 2004 to 2023 to analyze the incidence trend of meningococcal meningitis in China from 1990 to 2023 by Joinpoint regression method. Based on the data of the national meningococcal meningitis surveillance information reporting and management system from 2006 to 2023, the incidence of meningococcal meningitis caused by different serogroups of was described and analyzed, and the trend test was performed to analyze the change of the incidence of meningococcal meningitis caused by A, B, and C. The overall incidence of meningococcal meningitis in China showed a downward trend from 1990 to 2023 [average annual percent change (AAPC)=-14.80%, <0.001], with the most obvious decline from 2005 to 2012 [annual percent change (APC)=-31.01%, <0.001]. The incidence of meningococcal meningitis decreased in both men and women (AAPC=-14.69% and -15.05%, both <0.001). A total of 1 178 serogroup specific cases of meningococcal meningitis were reported in China from 2006 to 2023, the proportion of serogroup C was highest (32.5%), followed by unclassified (22.3%), B (20.1%), A (18.4%), W (4.5%), Y (2.0%) and X (0.2%). The results of trend test indicated that the incidence of meningococcal meningitis caused by A and C showed downward trends (both <0.001) and the incidence of meningococcal meningitis caused by B showed an upward trend in general population and young children (0-4 years old group) from 2006 to 2023 (both <0.05). The incidence of meningococcal meningitis showed a downward trend in China from 1990 to 2023, but it is still necessary to pay more attention to the incidence of meningococcal meningitis caused by B in age group aged 0-4 years and by multi serogroups at same time in general population.
了解1990年至2023年中国脑膜炎球菌性脑膜炎的发病趋势、2006年至2023年主要致病血清群及主要致病血清群引起的脑膜炎球菌性脑膜炎发病率的时间趋势，为脑膜炎球菌性脑膜炎的防控提供参考。本研究利用1990年至2003年《全国疫情资料汇编》数据及2004年至2023年中国法定传染病报告系统数据，采用Joinpoint回归法分析1990年至2023年中国脑膜炎球菌性脑膜炎的发病趋势。基于2006年至2023年全国脑膜炎球菌性脑膜炎监测信息报告管理系统数据，描述并分析不同血清群引起的脑膜炎球菌性脑膜炎发病率，进行趋势检验分析A、B、C群引起的脑膜炎球菌性脑膜炎发病率变化。1990年至2023年中国脑膜炎球菌性脑膜炎总体发病率呈下降趋势[平均年变化百分比（AAPC）=-14.80%，P<0.001]，2005年至201年下降最明显[年变化百分比（APC）=-31.01%，P<0.001]。男性和女性脑膜炎球菌性脑膜炎发病率均下降（AAPC分别为-14.69%和-15.05%，均P<0.001）。2006年至2023年中国共报告1178例血清群特异性脑膜炎球菌性脑膜炎病例，C群所占比例最高（32.5%），其次为未分类（22.3%）、B群（20.1%）、A群（18.4%）、W群（4.5%）、Y群（2.0%）和X群（0.2%）。趋势检验结果显示，2006年至2023年A群和C群引起的脑膜炎球菌性脑膜炎发病率呈下降趋势（均P<0.001），B群引起的脑膜炎球菌性脑膜炎发病率在一般人群和幼儿（0至4岁组）中总体呈上升趋势（均P<0.05）。1990年至2023年中国脑膜炎球菌性脑膜炎发病率呈下降趋势，但仍需关注0至4岁年龄组B群引起的脑膜炎球菌性脑膜炎发病率及一般人群中多血清群同时引起的脑膜炎球菌性脑膜炎发病率。
