多组学整合分析鉴定的 SOCS 家族在肝癌中的表达特征、免疫特征和预后价值。

Expression Characteristics, Immune Signature, and Prognostic Value of the SOCS Family Identified by Multiomics Integrative Analysis in Liver Cancer.

机构信息

Department of Special Treatment, Shanghai Eastern Hepatobiliary Surgery Hospital, Shanghai, China.

出版信息

Cancer Rep (Hoboken). 2024 Sep;7(9):e2161. doi: 10.1002/cnr2.2161.

DOI:10.1002/cnr2.2161

PMID:39307915

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11416904/

Abstract

BACKGROUND

Hepatocellular carcinoma (HCC) is a prevalent malignancy with a high mortality rate worldwide. Suppressor of cytokine signaling (SOCS) family members play important roles in the proliferation, metabolism, and immunity of HCC cells by regulating cytokines and growth factors. However, it remains uncertain whether the level of SOCS family members can affect the prognosis of HCC patients.

AIMS

This study aimed to comprehensively assess the role and mechanisms of SOCS family members in the development of HCC and to guide clinical selection.

METHODS

We investigated the expression levels of SOCS family genes in HCC patients and their associations with various clinicopathological characteristics. We also utilized a public database to analyze the changes in the expression, potential functions, transcription factors, and immune invasion of SOCS family members. Additionally, we examined the prognostic value of the SOC family for HCC and its correlation with the SOC family and ferroptosis-related genes.

RESULTS

This study revealed that the expression of SOCS2-7, and CISH was downregulated in HCC. The SOCS4, SOCS5, and SOCS7 genes were associated with the clinicopathological features of HCC patients. SOCS family genes are mainly related to the PIK3R3, GHR, and TNS4 pathways. Additionally, this study revealed that STAT3, PPAR-gamma 2, and IRF-2 are important transcription factors that regulate SOCS family members. The expression levels of SOCS family members are closely related to immune infiltration in liver cancer. The study also indicated that SOCS2 and SOCS4 are risk-related genes for predicting the prognosis of patients with liver cancer. Finally, this study suggested that the SOCS2 gene may be involved in the development and progression of HCC.

CONCLUSION

Our study enhances the current understanding of SOCS gene function in liver cancer and can help clinicians select appropriate drugs and predict the prognosis of HCC patients.

摘要

背景

肝细胞癌（HCC）是一种全球高发且死亡率较高的恶性肿瘤。细胞因子信号转导抑制因子（SOCS）家族成员通过调节细胞因子和生长因子在 HCC 细胞的增殖、代谢和免疫中发挥重要作用。然而，SOCS 家族成员的水平是否能影响 HCC 患者的预后仍不确定。

目的

本研究旨在全面评估 SOCS 家族成员在 HCC 发生发展中的作用和机制，为临床选择提供指导。

方法

我们检测了 HCC 患者 SOCS 家族基因的表达水平及其与各种临床病理特征的关系。我们还利用公共数据库分析 SOCS 家族成员的表达变化、潜在功能、转录因子和免疫浸润。此外，我们还研究了 SOC 家族对 HCC 的预后价值及其与 SOC 家族和铁死亡相关基因的相关性。

结果

本研究表明，SOCS2-7 和 CISH 在 HCC 中表达下调。SOCS4、SOCS5 和 SOCS7 基因与 HCC 患者的临床病理特征相关。SOCS 家族基因主要与 PIK3R3、GHR 和 TNS4 通路相关。此外，本研究还揭示了 STAT3、PPAR-γ2 和 IRF-2 是调节 SOCS 家族成员的重要转录因子。SOCS 家族成员的表达水平与肝癌的免疫浸润密切相关。研究还表明，SOCS2 和 SOCS4 是预测肝癌患者预后的风险相关基因。最后，本研究提示 SOCS2 基因可能参与 HCC 的发生发展。