Yun Niu, Yingrun Fan, Xuefeng Wang, Minghua Qiu, Jiangping Fan
College of Food Science and Technology, Yunnan Agricultural University, Kunming, China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.
Crit Rev Food Sci Nutr. 2024 Sep 22:1-26. doi: 10.1080/10408398.2024.2406485.
Chlorogenic acid (CGA) that exhibits various bioactivities holds promise as a natural and safe medicinal agent or food supplement for promoting human health. However, the direct formulation for treatment is severely limited by its low water solubility, poor bioavailability, low plasma stability, and side effects caused by high doses. Fortunately, nanotechnology is widely applied for drug delivery to overcome the partial disadvantages of traditional drug molecules or naturally active components. The properties of CGA containing multiple hydroxyl groups as a green reductant and stabilizer have made the development of CGA-loaded nanomaterials possible. In this review, recent advancements in the design of CGA-loaded nanomaterials based on organic or inorganic nanomaterials were discussed, and the positive effects of nanomaterials on the release properties of active molecules and their targeted distribution in biological systems were indicated. These nanomaterials enhance the physiological activity of CGA in the treatment of various diseases. Moreover, in the field of food, CGA-loaded nanocomposites have been found to optimize the mechanical properties of nano-food packaging, leading to an extended shelf life of food products. The findings of this review provide a valuable foundation and reference for the development of novel CGA-loaded nanomedicines and nano-food packaging.
具有多种生物活性的绿原酸（CGA）有望成为促进人类健康的天然安全药物或食品补充剂。然而，其直接用于治疗存在严重局限，因为它水溶性低、生物利用度差、血浆稳定性低，且高剂量会产生副作用。幸运的是，纳米技术被广泛应用于药物递送，以克服传统药物分子或天然活性成分的部分缺点。CGA含有多个羟基，具有作为绿色还原剂和稳定剂的特性，这使得负载CGA的纳米材料的开发成为可能。在这篇综述中，讨论了基于有机或无机纳米材料的负载CGA纳米材料设计的最新进展，并指出了纳米材料对活性分子释放特性及其在生物系统中靶向分布的积极影响。这些纳米材料增强了CGA在治疗各种疾病中的生理活性。此外，在食品领域，已发现负载CGA的纳米复合材料可优化纳米食品包装的机械性能，从而延长食品保质期。这篇综述的研究结果为新型负载CGA纳米药物和纳米食品包装的开发提供了有价值的基础和参考。
