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Br J Haematol. 2024 Dec;205(6):2248-2253. doi: 10.1111/bjh.19787. Epub 2024 Sep 22.
2
Acalabrutinib in combination with rituximab and lenalidomide in patients with relapsed or refractory follicular lymphoma: Results of the phase 1b open-label study (ACE-LY-003).阿卡拉布替尼联合利妥昔单抗和来那度胺治疗复发或难治性滤泡性淋巴瘤患者：1b期开放标签研究（ACE-LY-003）结果
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Acalabrutinib plus Obinutuzumab in Treatment-Naïve and Relapsed/Refractory Chronic Lymphocytic Leukemia.阿卡拉布替尼联合奥滨尤妥珠单抗治疗初治及复发/难治性慢性淋巴细胞白血病
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Acalabrutinib with or without obinutuzumab versus chlorambucil and obinutuzmab for treatment-naive chronic lymphocytic leukaemia (ELEVATE TN): a randomised, controlled, phase 3 trial.阿卡替尼联合或不联合奥滨尤妥珠单抗对比苯丁酸氮芥联合奥滨尤妥珠单抗治疗初治慢性淋巴细胞白血病（ELEVATE TN）：一项随机、对照、III 期临床试验。
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引用本文的文献

1
Acalabrutinib in combination with rituximab and lenalidomide in patients with relapsed or refractory follicular lymphoma: Results of the phase 1b open-label study (ACE-LY-003).阿卡拉布替尼联合利妥昔单抗和来那度胺治疗复发或难治性滤泡性淋巴瘤患者：1b期开放标签研究（ACE-LY-003）结果
Br J Haematol. 2025 Mar;206(3):887-898. doi: 10.1111/bjh.19951. Epub 2024 Dec 12.

本文引用的文献

1
Phase 3 SELENE study: ibrutinib plus BR/R-CHOP in previously treated patients with follicular or marginal zone lymphoma.SELENE 研究 3 期：伊布替尼联合 BR/R-CHOP 方案治疗滤泡性或边缘区淋巴瘤患者。
Blood Adv. 2023 Nov 28;7(22):7141-7150. doi: 10.1182/bloodadvances.2023010298.
2
ROSEWOOD: A Phase II Randomized Study of Zanubrutinib Plus Obinutuzumab Versus Obinutuzumab Monotherapy in Patients With Relapsed or Refractory Follicular Lymphoma.ROSEWOOD：泽布替尼联合奥滨尤妥珠单抗对比奥滨尤妥珠单抗单药治疗复发/难治滤泡性淋巴瘤患者的 II 期随机研究。
J Clin Oncol. 2023 Nov 20;41(33):5107-5117. doi: 10.1200/JCO.23.00775. Epub 2023 Jul 28.
3
Treatment patterns and outcomes in relapsed/refractory follicular lymphoma: results from the international SCHOLAR-5 study.复发/难治性滤泡性淋巴瘤的治疗模式和结局：来自国际 SCHOLAR-5 研究的结果。
Haematologica. 2023 Mar 1;108(3):822-832. doi: 10.3324/haematol.2022.281421.
4
Zanubrutinib monotherapy in relapsed/refractory indolent non-Hodgkin lymphoma.泽布替尼单药治疗复发/难治性惰性非霍奇金淋巴瘤。
Blood Adv. 2022 Jun 14;6(11):3472-3479. doi: 10.1182/bloodadvances.2021006083.
5
Bruton Tyrosine Kinase Inhibitors in B-Cell Malignancies: Their Use and Differential Features.布鲁顿酪氨酸激酶抑制剂在 B 细胞恶性肿瘤中的应用及其特点。
Target Oncol. 2022 Jan;17(1):69-84. doi: 10.1007/s11523-021-00857-8. Epub 2021 Dec 14.
6
Follicular lymphoma and macrophages: impact of approved and novel therapies.滤泡性淋巴瘤与巨噬细胞：已获批疗法和新型疗法的影响。
Blood Adv. 2021 Oct 26;5(20):4303-4312. doi: 10.1182/bloodadvances.2021005722.
7
Follicular lymphoma in the modern era: survival, treatment outcomes, and identification of high-risk subgroups.现代滤泡性淋巴瘤：生存、治疗结果和高危亚组的识别。
Blood Cancer J. 2020 Jul 17;10(7):74. doi: 10.1038/s41408-020-00340-z.
8
Ibrutinib as Treatment for Patients With Relapsed/Refractory Follicular Lymphoma: Results From the Open-Label, Multicenter, Phase II DAWN Study.伊布替尼治疗复发/难治性滤泡性淋巴瘤患者：来自开放标签、多中心、Ⅱ期 DAWN 研究的结果。
J Clin Oncol. 2018 Aug 10;36(23):2405-2412. doi: 10.1200/JCO.2017.76.8853. Epub 2018 May 31.
9
Single-agent ibrutinib in relapsed or refractory follicular lymphoma: a phase 2 consortium trial.单药伊布替尼治疗复发或难治性滤泡性淋巴瘤：一项 2 期联盟试验。
Blood. 2018 Jan 11;131(2):182-190. doi: 10.1182/blood-2017-09-804641. Epub 2017 Oct 26.
10
Acalabrutinib (ACP-196): A Covalent Bruton Tyrosine Kinase Inhibitor with a Differentiated Selectivity and In Vivo Potency Profile.阿卡拉布替尼（ACP-196）：一种具有独特选择性和体内药效学特征的共价布鲁顿酪氨酸激酶抑制剂。
J Pharmacol Exp Ther. 2017 Nov;363(2):240-252. doi: 10.1124/jpet.117.242909. Epub 2017 Sep 7.

阿卡替尼单药或联合利妥昔单抗治疗滤泡性淋巴瘤：一项开放标签研究。

Acalabrutinib alone or in combination with rituximab for follicular lymphoma: An open-label study.

作者信息

Strati Paolo, Champion Rebecca, Coleman Morton, Smith Sonali M, Venugopal Parameswaran, Martin Peter, Wood Andrew, Miller Kara, Christian Beth

机构信息

The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Norton Cancer Institute, Louisville, Kentucky, USA.

出版信息

Br J Haematol. 2024 Dec;205(6):2248-2253. doi: 10.1111/bjh.19787. Epub 2024 Sep 22.

DOI:10.1111/bjh.19787
PMID:39308028
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11637741/
Abstract

Acalabrutinib is a selective, second-generation Bruton tyrosine kinase inhibitor. In this open-label, parallel-group study, patients with relapsed/refractory (R/R) follicular lymphoma (FL) were randomised to either acalabrutinib monotherapy or acalabrutinib plus rituximab. An additional cohort of patients with treatment-naive (TN) FL received only the acalabrutinib-rituximab combination. Acalabrutinib-rituximab was well tolerated and active in R/R and TN FL; in the TN cohort the overall response rate was 92.3% with most remissions lasting over 4 years. Acalabrutinib monotherapy was also well tolerated and active in R/R FL. These results support further study of acalabrutinib alone and in combination with rituximab in FL.

摘要

阿卡替尼是一种选择性第二代布鲁顿酪氨酸激酶抑制剂。在这项开放标签、平行组研究中，复发/难治性（R/R）滤泡性淋巴瘤（FL）患者被随机分为阿卡替尼单药治疗组或阿卡替尼联合利妥昔单抗治疗组。另外一组初治（TN）FL患者仅接受阿卡替尼-利妥昔单抗联合治疗。阿卡替尼-利妥昔单抗耐受性良好，对R/R和TN FL均有活性；在TN队列中，总体缓解率为92.3%，大多数缓解持续超过4年。阿卡替尼单药治疗对R/R FL也具有良好的耐受性和活性。这些结果支持进一步研究阿卡替尼单药以及与利妥昔单抗联合用于FL的治疗。