Stem Cells and Regenerative Medicine Centre, Yenepoya Research Centre, Yenepoya (Deemed to be University), Mangalore, Karnataka, India.
Cell Biol Int. 2024 Dec;48(12):1802-1815. doi: 10.1002/cbin.12246. Epub 2024 Sep 23.
Pax-6 emerges as a critical transcription factor that guides the fate of stem cells towards neural lineages. Its expression influences the differentiation of neural progenitors into diverse neuronal subtypes, glial cells, and other neural cell types. Pax-6 operates with other regulatory factors to ensure the precise patterning and organization of the developing nervous system. The intricate interplay between Pax-6 and other signaling pathways, transcription factors, and epigenetic modifiers underpins the complicated balance between stem cell maintenance, proliferation, and differentiation in neuroectodermal and ocular contexts. Dysfunction of Pax-6 can lead to a spectrum of developmental anomalies, underscoring its importance in these processes. This review highlights the essential role of Pax-6 expression in neuroectodermal and ocular stem cells, shedding light on its significance in orchestrating the intricate journey from stem cell fate determination to the emergence of diverse neural and ocular cell types. The comprehensive understanding of Pax-6 function gained from a developmental biology perspective offers valuable insights into normal development and potential therapeutic avenues for neuroectodermal and ocular disorders.
Pax-6 作为一种关键的转录因子出现，指导干细胞向神经谱系的命运。它的表达影响神经祖细胞分化为不同的神经元亚型、神经胶质细胞和其他神经细胞类型。Pax-6 与其他调节因子一起运作，以确保发育中神经系统的精确模式形成和组织。Pax-6 与其他信号通路、转录因子和表观遗传修饰因子之间的复杂相互作用，支撑了神经外胚层和眼部环境中干细胞维持、增殖和分化之间的复杂平衡。Pax-6 的功能障碍会导致一系列发育异常，突显了它在这些过程中的重要性。本综述强调了 Pax-6 表达在神经外胚层和眼部干细胞中的重要作用，揭示了其在协调从干细胞命运决定到出现多种神经和眼部细胞类型的复杂过程中的重要意义。从发育生物学角度获得的对 Pax-6 功能的全面理解为神经外胚层和眼部疾病的正常发育和潜在治疗途径提供了有价值的见解。
