迈向精神分裂症病因学的统一理论。

Towards a unified theory of the aetiology of schizophrenia.

机构信息

Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, China; and Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China.

Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, China; Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China; MOE Frontiers Center for Brain Science, Fudan University, China; and Zhangjiang Fudan International Innovation Center, Shanghai, China.

出版信息

Br J Psychiatry. 2024 Aug;225(2):299-301. doi: 10.1192/bjp.2024.65.

DOI:10.1192/bjp.2024.65

PMID:39308237

Abstract

We emphasise the existence of two distinct neurophysiological subtypes in schizophrenia, characterised by different sites of initial grey matter loss. We review evidence for potential neuromolecular mechanisms underlying these subtypes, proposing a biologically based disease classification approach to unify macro- and micro-scale neural abnormalities of schizophrenia.

摘要

我们强调精神分裂症存在两种不同的神经生理亚型，其特征是初始灰质损失的部位不同。我们回顾了这些亚型潜在神经分子机制的证据，提出了一种基于生物学的疾病分类方法，以统一精神分裂症的宏观和微观神经异常。