探究偶氮苯 G-四链体配体的结合和抗寄生虫功效，以研究 G4 配体设计。
Probing the binding and antiparasitic efficacy of azobenzene G-quadruplex ligands to investigate G4 ligand design.
机构信息
School of Chemistry, Cantock's Close, University of Bristol, BS8 1TS, UK.
Instituto de Parasitología y Biomedicina López Neyra, CSIC, PTS Granada, Avenida del Conocimiento, 17, 18016, Armilla, Granada, Spain.
出版信息
Chem Commun (Camb). 2024 Oct 8;60(81):11520-11523. doi: 10.1039/d4cc03106g.
Abstract
Novel strategies against parasitic infections are of great importance. Here, we describe a G4 DNA ligand with subnanomolar antiparasitic activity against and a remarkable selectivity index (IC MRC-5/) of 2285-fold. We also correlate the impact of small structural changes to G4 binding activity and antiparasitic activity.
摘要
针对寄生虫感染的新策略具有重要意义。在这里，我们描述了一种具有亚纳摩尔抗寄生虫活性的 G4 DNA 配体，对 和 MRC-5/ 的选择性指数（IC ）高达 2285 倍。我们还将小结构变化对 G4 结合活性和抗寄生虫活性的影响进行了关联。
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