Li Min, Ma Rongyue, Li Qing, Guo Min
Otorhinolaryngology Department, First Affiliated Hospital of Kunming Medical University Kunming, Yunnan, China.
Nephrology Department, First Affiliated Hospital of Kunming Medical University Kunming, Yunnan, China.
Am J Stem Cells. 2024 Aug 25;13(4):212-221. doi: 10.62347/AEIV5813. eCollection 2024.
Sensorineural deafness mainly occurs due to damage to hair cells, and advances in stem cell technology, especially the application of induced pluripotent stem cells (iPSCs) and adult stem cells, provides new possibilities for hair cell regeneration. This review describes the basic knowledge of stem cells and their important applications in regenerative medicine, as well as recent progress in stem cell research in the field of hair cell regeneration, especially the induced differentiation of hair-like cells. At the same time, we also point out the challenges facing current research, including differentiation efficiency, cell stability issues, and treatment safety and long-term efficacy considerations. Finally, we look forward to the direction of future research, and emphasize the importance of the cell differentiation mechanism, simulation of the inner ear microenvironment, safety assessment, and personalized treatment strategies. In conclusion, despite many challenges, stem cell technology has shown great potential in the field of hearing research and is expected to bring revolutionary treatment options for patients with sensorineural hearing loss in the future.
感音神经性耳聋主要是由于毛细胞受损引起的，而干细胞技术的进步，特别是诱导多能干细胞（iPSC）和成体干细胞的应用，为毛细胞再生提供了新的可能性。本综述介绍了干细胞的基础知识及其在再生医学中的重要应用，以及毛细胞再生领域干细胞研究的最新进展，特别是类毛细胞的诱导分化。同时，我们也指出了当前研究面临的挑战，包括分化效率、细胞稳定性问题以及治疗安全性和长期疗效考量。最后，我们展望了未来研究的方向，并强调了细胞分化机制、内耳微环境模拟、安全性评估和个性化治疗策略的重要性。总之，尽管面临诸多挑战，干细胞技术在听力研究领域已展现出巨大潜力，有望在未来为感音神经性听力损失患者带来革命性的治疗选择。
