Fu Qi, Zhang Cuiping, Yang Yujiao, Teng Ruoling, Liu Fenfen, Liu Ping, Wang Long, Wang Jiao, Chen Yanan, Ding Yi
Department of Geriatrics, The First People's Hospital of Changzhou (The Third Affiliated Hospital of Soochow University), Changzhou 213000, Jiangsu, China.
J Clin Transl Endocrinol. 2024 Sep 7;37:100369. doi: 10.1016/j.jcte.2024.100369. eCollection 2024 Sep.
Vertebral compression fractures (VCFs) are prevalent in patients with osteoporosis and pose significant health risks. Although chronic low-grade inflammation plays a crucial role in the pathogenesis of osteoporosis, the relationship between various inflammatory indices and the occurrence of fractures remains unclear.
This study aims to evaluate the correlation between multiple inflammatory indices, neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammatory index (SII), and systemic inflammatory response index (SIRI), and VCFs, to explore the significance of these indices in clinical application.
Clinical data of 310 patients diagnosed with osteoporosis from November 2020 to June 2023 in the hospital were collected. The general conditions between fracture and non-fracture groups were described. Spearman analysis and binary logistic regression analysis were used to assess the relationship between inflammatory indices and VCFs. Receiver operating characteristic curve was used to evaluate the diagnostic efficacy of these inflammatory indices for VCFs.
VCFs were diagnosed in 43.55 % of patients with osteoporosis. NLR(ρ = 0.169, P=0.003), MLR(ρ = 0.293, P<0.001), SII(ρ = 0.126, P=0.027), and SIRI(ρ = 0.273, P<0.001) were positively correlated with the occurrence of VCFs. NLR(OR=1.480, 95 %CI 1.114 ∼ 1.966, P=0.007), MLR(multiplied by 100, OR=1.048, 95 %CI 1.011 ∼ 1.087, P=0.011), and SIRI(OR=3.327, 95 %CI 1.510 ∼ 7.330, P=0.003) were independent risk factors for VCFs, hip bone mineral density (BMD) (OR=0.011, 95 %CI 0.001 ∼ 0.151, P=0.001) was an independent protective factor for VCFs. MLR(AUC 0.671, 95 % CI=0.610 ∼ 0.732, P <0.001) had relatively high clinical diagnostic efficacy.
The neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and systemic inflammatory response index (SIRI) are independent risk factors for vertebral compression fractures.
椎体压缩性骨折（VCF）在骨质疏松症患者中很常见，并带来重大健康风险。尽管慢性低度炎症在骨质疏松症的发病机制中起关键作用，但各种炎症指标与骨折发生之间的关系仍不清楚。
本研究旨在评估多种炎症指标，即中性粒细胞与淋巴细胞比值（NLR）、单核细胞与淋巴细胞比值（MLR）、血小板与淋巴细胞比值（PLR）、全身免疫炎症指数（SII）和全身炎症反应指数（SIRI）与VCF之间的相关性，以探讨这些指标在临床应用中的意义。
收集2020年11月至2023年6月在该医院诊断为骨质疏松症的310例患者的临床资料。描述骨折组和非骨折组的一般情况。采用Spearman分析和二元逻辑回归分析评估炎症指标与VCF之间的关系。采用受试者工作特征曲线评估这些炎症指标对VCF的诊断效能。
43.55%的骨质疏松症患者被诊断为VCF。NLR（ρ = 0.169，P = 0.003）、MLR（ρ = 0.293，P < 0.001）、SII（ρ = 0.126，P = 0.027）和SIRI（ρ = 0.273，P < 0.001）与VCF的发生呈正相关。NLR（OR = 1.480，95%CI 1.114 ∼ 1.966，P = 0.007）、MLR（乘以100，OR = 1.048，95%CI 1.011 ∼ 1.087，P = 0.011）和SIRI（OR = 3.327，95%CI 1.510 ∼ 7.330，P = 0.003）是VCF的独立危险因素，髋部骨密度（BMD）（OR = 0.011，95%CI 0.001 ∼ 0.151，P = 0.
