School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, China.
School of Biomedical Engineering, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China.
Front Immunol. 2024 Sep 6;15:1420463. doi: 10.3389/fimmu.2024.1420463. eCollection 2024.
With the outbreak of the coronavirus disease 2019 (COVID-19), reductions in T-cell function and exhaustion have been observed in patients post-infection of COVID-19. T cells are key mediators of anti-infection and antitumor, and their exhaustion increases the risk of compromised immune function and elevated susceptibility to cancer. Non-small cell lung cancer (NSCLC) is the most common subtype of lung cancer with high incidence and mortality. Although the survival rate after standard treatment such as surgical treatment and chemotherapy has improved, the therapeutic effect is still limited due to drug resistance, side effects, and recurrence. Recent advances in molecular biology and immunology enable the development of highly targeted therapy and immunotherapy for cancer, which has driven cancer therapies into individualized treatments and gradually entered clinicians' views for treating NSCLC. Currently, with the development of photosensitizer materials, phototherapy has been gradually applied to the treatment of NSCLC. This review provides an overview of recent advancements and limitations in different treatment strategies for NSCLC under the background of COVID-19. We discuss the latest advances in phototherapy as a promising treatment method for NSCLC. After critically examining the successes, challenges, and prospects associated with these treatment modalities, their profound prospects were portrayed.
随着 2019 年冠状病毒病（COVID-19）的爆发，COVID-19 感染后患者的 T 细胞功能和耗竭已经被观察到。T 细胞是抗感染和抗肿瘤的关键介质，其耗竭会增加免疫功能受损和癌症易感性增加的风险。非小细胞肺癌（NSCLC）是最常见的肺癌亚型，发病率和死亡率都很高。尽管手术治疗和化疗等标准治疗后的生存率有所提高，但由于耐药性、副作用和复发，治疗效果仍然有限。分子生物学和免疫学的最新进展使癌症的高度靶向治疗和免疫治疗得以发展，这推动了癌症治疗进入个体化治疗，并逐渐进入临床医生治疗 NSCLC 的视野。目前，随着光动力治疗材料的发展，光疗已逐渐应用于 NSCLC 的治疗。本综述在 COVID-19 的背景下，概述了不同治疗策略治疗 NSCLC 的最新进展和局限性。我们讨论了光疗作为 NSCLC 有前途的治疗方法的最新进展。在批判性地审查了这些治疗方法的成功、挑战和前景后，描绘了它们的深远前景。
