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Higher efficacy of intravenous thrombolysis in patients with acute ischemic stroke taking direct oral anticoagulants-A new relevant hypothesis.直接口服抗凝剂治疗的急性缺血性卒中患者静脉溶栓疗效更高——一个新的相关假说
Front Neurol. 2024 Sep 6;15:1458697. doi: 10.3389/fneur.2024.1458697. eCollection 2024.
2
Safety and efficacy of intravenous thrombolysis in patients with acute ischemic stroke taking direct oral anticoagulants prior to stroke: a meta-analysis.直接口服抗凝剂治疗的急性缺血性脑卒中患者静脉溶栓的安全性和有效性：一项荟萃分析。
J Neurol. 2023 Sep;270(9):4192-4200. doi: 10.1007/s00415-023-11815-x. Epub 2023 Jun 14.
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Intravenous Thrombolysis With Alteplase at 0.6 mg/kg in Patients With Ischemic Stroke Taking Direct Oral Anticoagulants.直接口服抗凝剂治疗的缺血性脑卒中患者使用 0.6mg/kg 阿替普酶静脉溶栓治疗。
J Am Heart Assoc. 2022 Oct 4;11(19):e025809. doi: 10.1161/JAHA.122.025809. Epub 2022 Sep 21.
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Safety of Endovascular Thrombectomy for Acute Ischaemic Stroke in Anticoagulated Patients Ineligible for Intravenous Thrombolysis.抗凝治疗且不符合静脉溶栓条件的急性缺血性卒中患者血管内血栓切除术的安全性
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Association of Recent Use of Non-Vitamin K Antagonist Oral Anticoagulants With Intracranial Hemorrhage Among Patients With Acute Ischemic Stroke Treated With Alteplase.近期使用非维生素 K 拮抗剂口服抗凝剂与阿替普酶治疗的急性缺血性脑卒中患者颅内出血的相关性。
JAMA. 2022 Feb 22;327(8):760-771. doi: 10.1001/jama.2022.0948.
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Safety of Intravenous Thrombolysis among Stroke Patients Taking New Oral Anticoagulants--Case Series and Systematic Review of Reported Cases.服用新型口服抗凝剂的中风患者静脉溶栓治疗的安全性——病例系列及报告病例的系统评价
J Stroke Cerebrovasc Dis. 2015 Dec;24(12):2685-93. doi: 10.1016/j.jstrokecerebrovasdis.2015.07.021. Epub 2015 Nov 2.
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Intravenous Thrombolysis for Acute Ischemic Stroke in Patients With Recent Direct Oral Anticoagulant Use: A Systematic Review and Meta-Analysis.近期直接口服抗凝药物使用患者的急性缺血性脑卒中的静脉溶栓治疗：系统评价和荟萃分析。
J Am Heart Assoc. 2023 Dec 19;12(24):e031669. doi: 10.1161/JAHA.123.031669. Epub 2023 Dec 18.
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[Systemic thrombolysis after the administration of idarucizumab in acute ischemic stroke].[急性缺血性卒中患者接受艾达司珠单抗治疗后进行全身溶栓]
Ideggyogy Sz. 2017 Jul 30;70(7-8):284-288. doi: 10.18071/isz.70.0284.
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Revascularization outcomes following acute ischemic stroke in patients taking direct oral anticoagulants: a single hospital cohort study.服用直接口服抗凝剂的急性缺血性卒中患者的血管再通结局：一项单中心队列研究
J Thromb Thrombolysis. 2021 Jan;51(1):194-202. doi: 10.1007/s11239-020-02168-7.

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Intravenous thrombolysis before endovascular treatment in acute posterior circulation occlusions, what's next?急性后循环闭塞血管内治疗前的静脉溶栓，接下来该怎么做？
Front Neurol. 2025 Jul 16;16:1631936. doi: 10.3389/fneur.2025.1631936. eCollection 2025.
2
Intravenous Thrombolysis in Patients Taking Direct Oral Anticoagulation Treatment Before Stroke Onset: Results from the Safe Implementations of Treatments in Stroke International Stroke Registry.卒中发作前接受直接口服抗凝治疗患者的静脉溶栓：来自国际卒中登记处卒中治疗安全实施的结果
Ann Neurol. 2025 Jun;97(6):1205-1214. doi: 10.1002/ana.27189. Epub 2025 Feb 4.

本文引用的文献

1
Intravenous thrombolysis in patients with recent intake of direct oral anticoagulants: A target trial analysis after the liberalization of institutional guidelines.近期服用直接口服抗凝药物患者的静脉溶栓治疗：机构指南放宽后的目标试验分析。
Eur Stroke J. 2024 Dec;9(4):959-967. doi: 10.1177/23969873241252751. Epub 2024 May 13.
2
Intravenous Thrombolysis for Acute Ischemic Stroke in Patients With Recent Direct Oral Anticoagulant Use: A Systematic Review and Meta-Analysis.近期直接口服抗凝药物使用患者的急性缺血性脑卒中的静脉溶栓治疗：系统评价和荟萃分析。
J Am Heart Assoc. 2023 Dec 19;12(24):e031669. doi: 10.1161/JAHA.123.031669. Epub 2023 Dec 18.
3
Meta-analysis of outcomes following intravenous thrombolysis in patients with ischemic stroke on direct oral anticoagulants.直接口服抗凝剂治疗的缺血性脑卒中患者静脉溶栓后结局的荟萃分析。
BMC Neurol. 2023 Dec 15;23(1):440. doi: 10.1186/s12883-023-03498-8.
4
Risk of Bleeding Following Non-Vitamin K Antagonist Oral Anticoagulant Use in Patients With Acute Ischemic Stroke Treated With Alteplase.非维生素 K 拮抗剂口服抗凝剂在接受阿替普酶治疗的急性缺血性脑卒中患者中的出血风险。
JAMA Intern Med. 2024 Jan 1;184(1):37-45. doi: 10.1001/jamainternmed.2023.6160.
5
Evolving Thrombolytics: from Alteplase to Tenecteplase.不断发展的溶栓药物：从阿替普酶到替奈普酶。
Neurotherapeutics. 2023 Apr;20(3):664-678. doi: 10.1007/s13311-023-01391-3. Epub 2023 Jun 5.
6
Intravenous Thrombolysis in Patients With Ischemic Stroke and Recent Ingestion of Direct Oral Anticoagulants.缺血性脑卒中且近期服用直接口服抗凝剂患者的静脉溶栓治疗。
JAMA Neurol. 2023 Mar 1;80(3):233-243. doi: 10.1001/jamaneurol.2022.4782.
7
Intravenous Thrombolysis With Alteplase at 0.6 mg/kg in Patients With Ischemic Stroke Taking Direct Oral Anticoagulants.直接口服抗凝剂治疗的缺血性脑卒中患者使用 0.6mg/kg 阿替普酶静脉溶栓治疗。
J Am Heart Assoc. 2022 Oct 4;11(19):e025809. doi: 10.1161/JAHA.122.025809. Epub 2022 Sep 21.
8
Characterising acute ischaemic stroke thrombi: insights from histology, imaging and emerging impedance-based technologies.从组织学、影像学和新兴阻抗技术角度分析急性缺血性脑卒中血栓。
Stroke Vasc Neurol. 2022 Aug;7(4):353-363. doi: 10.1136/svn-2021-001038. Epub 2022 Mar 3.
9
Association Between Prior Anticoagulation and Thrombus Composition in Mechanical Thrombectomy Patients with Atrial Fibrillation.心房颤动机械取栓患者既往抗凝治疗与血栓成分之间的关联
J Stroke Cerebrovasc Dis. 2022 Apr;31(4):106347. doi: 10.1016/j.jstrokecerebrovasdis.2022.106347. Epub 2022 Feb 12.
10
Association of Recent Use of Non-Vitamin K Antagonist Oral Anticoagulants With Intracranial Hemorrhage Among Patients With Acute Ischemic Stroke Treated With Alteplase.近期使用非维生素 K 拮抗剂口服抗凝剂与阿替普酶治疗的急性缺血性脑卒中患者颅内出血的相关性。
JAMA. 2022 Feb 22;327(8):760-771. doi: 10.1001/jama.2022.0948.

Higher efficacy of intravenous thrombolysis in patients with acute ischemic stroke taking direct oral anticoagulants-A new relevant hypothesis.

作者信息

Frol Senta, Pretnar Oblak Janja, Kermer Pawel, Ntaios George, Papanagiotou Panagiotis, Šabovič Mišo

机构信息

Department of Vascular Neurology, University Medical Center Ljubljana, Ljubljana, Slovenia.

Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

出版信息

Front Neurol. 2024 Sep 6;15:1458697. doi: 10.3389/fneur.2024.1458697. eCollection 2024.

DOI:10.3389/fneur.2024.1458697
PMID:39309266
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11412810/
Abstract
摘要