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英国主动脉瓣介入治疗的地理不平等:来自英国经导管主动脉瓣植入注册中心和国家成人心脏手术审计的报告

Geographical Inequality in Access to Aortic Valve Intervention in England: A Report from the UK Transcatheter Aortic Valve Implantation Registry and National Adult Cardiac Surgery Audit.

作者信息

Aktaa Suleman, Ali Noman, Ludman Peter F, Curzen Nick, Goodwin Andrew T, Hildick-Smith David, Kharbanda Rajesh K, Jones Peter D, Manuel Sue, Phanthala Satya, Blackman Daniel J

机构信息

Department of Cardiology, Leeds Teaching Hospitals NHS Trust Leeds, UK.

Institute of Cardiovascular Sciences, University of Birmingham Birmingham, UK.

出版信息

Interv Cardiol. 2024 Aug 28;19:e15. doi: 10.15420/icr.2024.19. eCollection 2024.

Abstract

BACKGROUND

For patients with severe aortic stenosis, transcatheter aortic valve implantation (TAVI) is a less invasive but equally effective treatment option compared with surgical aortic valve replacement (SAVR). In 2019, we reported low rates of TAVI in the UK compared with other countries in western Europe and highlighted profound geographical variation in TAVI care. Here, we provide contemporary data on access to aortic valve replacement by either TAVI or SAVR across clinical commissioning groups in England.

METHODS

We obtained aggregated data from the UK TAVI registry and the National Adult Cardiac Surgery Audit between 2019 and 2023. Rates of TAVI and SAVR procedures per million population were reported by clinical commissioning groups. The relationship between TAVI and SAVR rates was determined using Pearson correlation coefficients.

RESULTS

In 2022/23, the rates of TAVI and SAVR in England were 136 per million population and 60 per million population, respectively. The observed increase in TAVI rates since 2019/20 corresponded with a decline in SAVR rates. There remains substantial variation in access to both procedures, with an over tenfold variation in TAVI rates, and an over fourfold variation in SAVR rates across clinical commissioning groups in England. No relationship was identified between the rates of TAVI and those for SAVR (correlation coefficient 0.06).

CONCLUSION

Geographical heterogeneity in access to TAVI persists over time, with the low rates of TAVI in many areas not compensated for by higher rates of SAVR, indicating an overall inequality in the treatment of severe aortic stenosis.

摘要

背景

对于重度主动脉瓣狭窄患者,经导管主动脉瓣植入术(TAVI)与外科主动脉瓣置换术(SAVR)相比,是一种侵入性较小但同样有效的治疗选择。2019年,我们报告称英国的TAVI率与西欧其他国家相比很低,并强调了TAVI治疗存在显著的地域差异。在此,我们提供了关于英格兰各临床委托组通过TAVI或SAVR进行主动脉瓣置换的可及性的当代数据。

方法

我们获取了2019年至2023年期间英国TAVI注册中心和国家成人心脏手术审计的汇总数据。各临床委托组报告了每百万人口的TAVI和SAVR手术率。使用Pearson相关系数确定TAVI率和SAVR率之间的关系。

结果

在2022/23年度,英格兰的TAVI率和SAVR率分别为每百万人口136例和60例。自2019/20年度以来观察到的TAVI率上升与SAVR率下降相对应。两种手术的可及性仍存在很大差异,英格兰各临床委托组的TAVI率差异超过十倍,SAVR率差异超过四倍。未发现TAVI率与SAVR率之间存在关联(相关系数为0.06)。

结论

随着时间推移,TAVI可及性的地域异质性持续存在,许多地区的TAVI率较低并未因较高的SAVR率而得到弥补,这表明在重度主动脉瓣狭窄的治疗中总体存在不平等。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42f4/11413983/4b264fb6c1b9/icr-19-e15-g001.jpg

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