Huang Nan, Lu Bing, Zhu Zhuan-Zhuan, Zhu Xiang-Yun, Chen Sheng, Shu Zhi-Yi, Liu Gai-Fang, Peng You-Fan, Li Ling
Department of Endocrinology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, 210009, People's Republic of China.
Key Laboratory of Environmental Medicine Engineering of Ministry of Education, Southeast University, Nanjing, Jiangsu, 210009, People's Republic of China.
Diabetes Metab Syndr Obes. 2024 Sep 16;17:3447-3453. doi: 10.2147/DMSO.S477836. eCollection 2024.
Insulin resistance is associated with kidney impairment in patients with type 2 diabetes mellitus (T2DM). The triglyceride glucose-body mass index (TyG-BMI), which combines the TyG index with body mass index (BMI), has received significant attention as a tool for evaluating insulin resistance. Thus, the aim of this study was to explore the association between TyG-BMI and kidney impairment in patients with type 2 diabetes mellitus (T2DM).
The cross-sectional analysis included 1080 patients with T2DM, and data were collected retrospectively. TyG-BMI was calculated by fasting blood glucose, triglyceride, and body mass index.
TyG-BMI was significantly higher in T2DM patients with albuminuria than those without albuminuria (232.16 [206.52-268.02] vs 229.83 [206.11-255.64], =0.023). T2DM patients with chronic kidney disease (CKD) showed a significantly higher value of TyG-BMI compared with those without CKD (232.23 [206.46-268.28] vs 229.73 [206.11-255.49], =0.014). Correlation analysis showed a significantly positive association between TyG-BMI and metabolic parameters including BMI (r = 0.866, < 0.001), TG (r = 0.630, < 0.001), TC (r = 0.119, < 0.001), HDL-C (r = -0.374, < 0.001), FBG (r = 0.297, < 0.001), and HbA1c (r = 0.116, < 0.001) in patients with T2DM. The binary logistic regression analysis found that TyG-BMI was an independent factor for albuminuria (OR = 1.004, 95% CI: 1.001-1.008, = 0.010) and CKD (OR = 1.005, 95% CI: 1.001-1.008, = 0.005) in patients with T2DM respectively.
The study suggests that TyG-BMI is associated with kidney impairment in patients with T2DM. Given that TyG-BMI is a novel parameter of insulin resistance, the study results indicates that clinicians should pay close attention to screening for kidney impairment in T2DM patients with insulin resistance.
胰岛素抵抗与2型糖尿病（T2DM）患者的肾脏损害相关。甘油三酯葡萄糖-体重指数（TyG-BMI）将TyG指数与体重指数（BMI）相结合，作为评估胰岛素抵抗的工具受到了广泛关注。因此，本研究旨在探讨TyG-BMI与2型糖尿病（T2DM）患者肾脏损害之间的关联。
横断面分析纳入了1080例T2DM患者，数据进行回顾性收集。TyG-BMI通过空腹血糖、甘油三酯和体重指数计算得出。
有蛋白尿的T2DM患者的TyG-BMI显著高于无蛋白尿的患者（232.16[206.52 - 268.02]对比229.83[206.11 - 255.64]，P = 0.023）。患有慢性肾脏病（CKD）的T2DM患者的TyG-BMI值显著高于无CKD的患者（232.23[206.46 - 268.28]对比229.73[206.11 - 255.49]，P = 0.014）。相关性分析显示，在T2DM患者中，TyG-BMI与包括BMI（r = 0.866，P < 0.001）、TG（r = 0.630，P < 0.001）、TC（r = 0.119，P < 0.001）、HDL-C（r = -0.374，P < 0.001）、FBG（r = 0.297，P < 0.001）和HbA1c（r = 0.116，P < 0.001）在内的代谢参数呈显著正相关。二元逻辑回归分析发现，TyG-BMI分别是T2DM患者蛋白尿（OR = 1.004，95%CI：1.001 - 1.008，P = 0.010）和CKD（OR = 1.005，95%CI：1.001 - 1.008，P = 0.005）的独立因素。
该研究表明TyG-BMI与T2DM患者的肾脏损害相关。鉴于TyG-BMI是胰岛素抵抗的一个新参数，研究结果表明临床医生应密切关注对存在胰岛素抵抗的T2DM患者进行肾脏损害筛查。
