环氧乙烷接枝共聚物可降低脂质纳米颗粒的免疫原性。

Qi Yalin, Han Hesong, Liu Albert, Zhao Sheng, Lawanprasert Atip, Nielsen Josefine Eilsø, Choudhary Hema, Liang Dengpan, Barron Annelise E, Murthy Niren

Department of Bioengineering, University of California, Berkeley Berkeley California 94720 USA

Innovative Genomics Institute (IGI) Berkeley California 94704 USA.

RSC Adv. 2024 Sep 20;14(41):30071-30076. doi: 10.1039/d4ra05007j. eCollection 2024 Sep 18.

Lipid nanoparticle (LNP)/mRNA complexes have great therapeutic potential but their PEG chains can induce the production of anti-PEG antibodies. New LNPs that do not contain PEG are greatly needed. We demonstrate here that poly-glutamic acid-ethylene oxide graft copolymers can replace the PEG on LNPs and outperform PEG-LNPs after chronic administration.

脂质纳米颗粒（LNP）/mRNA复合物具有巨大的治疗潜力，但其聚乙二醇（PEG）链可诱导抗PEG抗体的产生。因此，非常需要不含PEG的新型LNP。我们在此证明，聚谷氨酸-环氧乙烷接枝共聚物可以取代LNP上的PEG，并且在长期给药后其性能优于PEG-LNP。