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黄曲霉毒素B1对血清钙利用的影响。

The effect of aflatoxin B1 on the utilization of serum calcium.

作者信息

Nassar A Y, Galal A F, Mohamed M A, Megalla S E, Hafez A H

出版信息

Mycopathologia. 1985 Aug;91(2):127-31. doi: 10.1007/BF00436548.

Abstract

The mathematical analysis for plasma disappearance curve of aflatoxicosed animals, subsequently injected with 45Ca was determined. The analysis showed that the three main compartments of the calcium pool (plasma, bone and the labile calcium pool on the surface of bone and soft tissues) had been affected. Specifically, the fractional rate constant for migration of 45Ca from plasma pool to the labile pool had been diminished to its third value. This led to a corresponding reduction in the calcium content of the bone ash. The probable mechanism by which aflatoxin B1 affects calcium dynamics may be interpreted by the inhibitory effect of aflatoxin in the hydroxylation mechanism of vitamin D3 into an active intermediate. During aflatoxicosis (induction of 15 days) the animals entered a state of calcium deficiency, secondary to intestinal absorption inhibition. This was followed by bone resorption and disturbance of the fractional removal rate constant among different calcium compartments.

摘要

对注射了45Ca的黄曲霉毒素中毒动物的血浆消失曲线进行了数学分析。分析表明,钙池的三个主要部分(血浆、骨骼以及骨骼和软组织表面的不稳定钙池)受到了影响。具体而言,45Ca从血浆池迁移到不稳定池的分数速率常数已降至其三分之一。这导致骨灰中钙含量相应降低。黄曲霉毒素B1影响钙动力学的可能机制可以通过黄曲霉毒素对维生素D3羟基化形成活性中间体机制的抑制作用来解释。在黄曲霉毒素中毒期间(诱导15天),动物进入钙缺乏状态,继发于肠道吸收抑制。随后是骨吸收以及不同钙区室之间分数清除率常数的紊乱。

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