Liu Ya, Ding Haoyuan, Cao Jianpeng, Liu Guangfu, Chen Yue, Huang Zhanwen
Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan, China.
Front Oncol. 2024 Sep 6;14:1436009. doi: 10.3389/fonc.2024.1436009. eCollection 2024.
To investigate the feasibility of [Ga]Ga-FAPI PET/CT in brain tumor imaging and to compare it with [F]F-FDG PET/CT.
25 patients with MRI-suspected brain tumors were included in the study. They underwent whole body [F]F-FDG PET/CT and [Ga]Ga-FAPI PET/CT and brain scans. The target-to-background ratio (TBR) of brain tumors was calculated with the background of surrounding normal brain tissues uptake. The SUVmax and TBR of [F]F-FDG PET/CT and [Ga]Ga-FAPI PET/CT were compared. Additionally, the correlation between the uptake of the tracer by lesions with the greatest diameter of the lesion, the breadth of the oedema band, and the enhancement scores of the MRI enhancement scans was analyzed.
[Ga]Ga-FAPI PET/CT was superior to [F]F-FDG PET/CT for lesion detection, especially for brain metastases. Among gliomas, only high-grade gliomas uptake [Ga]Ga-FAPI. Compared with [F]F-FDG PET/CT, [Ga]Ga-FAPI PET/CT had a lower SUVmax but a significantly better TBR. On [Ga]Ga-FAPI PET/CT, the TBR may be associated with brain tumor blood-brain barrier disruption.
[Ga]Ga-FAPI PET/CT is a promising imaging tool for the assessment of brain tumors. Lack of physiological uptake of [Ga]Ga-FAPI in normal brain parenchyma results in high TBR values, leading to better visualization of lesions and contributing to subsequent targeted therapy studies.
Clinical utility of [Ga]Ga-FAPI PET/CT in brain tumors remains unclear, and there aren't many similar studies in the literature. We evaluated the role of [Ga]Ga-FAPI PET/CT in diagnosing brain tumors.
探讨[镓]镓-FAPI PET/CT在脑肿瘤成像中的可行性，并将其与[氟]氟-FDG PET/CT进行比较。
本研究纳入25例MRI怀疑患有脑肿瘤的患者。他们接受了全身[氟]氟-FDG PET/CT和[镓]镓-FAPI PET/CT检查及脑部扫描。以周围正常脑组织摄取为背景计算脑肿瘤的靶本底比（TBR）。比较[氟]氟-FDG PET/CT和[镓]镓-FAPI PET/CT的SUVmax和TBR。此外，分析了病灶摄取示踪剂与最大病灶直径、水肿带宽度以及MRI增强扫描强化评分之间的相关性。
[镓]镓-FAPI PET/CT在病灶检测方面优于[氟]氟-FDG PET/CT，尤其是在脑转移瘤方面。在胶质瘤中，只有高级别胶质瘤摄取[镓]镓-FAPI。与[氟]氟-FDG PET/CT相比，[镓]镓-FAPI PET/CT的SUVmax较低，但TBR明显更好。在[镓]镓-FAPI PET/CT上，TBR可能与脑肿瘤血脑屏障破坏有关。
[镓]镓-FAPI PET/CT是一种有前景的脑肿瘤评估成像工具。正常脑实质中[镓]镓-FAPI缺乏生理性摄取导致高TBR值，从而使病灶显示更好，并有助于后续的靶向治疗研究。
[镓]镓-FAPI PET/CT在脑肿瘤中的临床应用仍不明确，文献中类似研究较少。我们评估了[镓]镓-FAPI PET/CT在诊断脑肿瘤中的作用。
