Pan Ruoxin, Wang Chuang, Gu Duoduo, Meng Xiaoqi, Liu Tingwei, Zhong Hui, Gong Qixing, Xu Yang
Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Department of Dermatology, Taizhou Hospital of Traditional Chinese Medicine, Taizhou, 225300, China.
Heliyon. 2024 Sep 10;10(18):e37732. doi: 10.1016/j.heliyon.2024.e37732. eCollection 2024 Sep 30.
Epithelioid hemangioma (EHE) is a rarely malignant tumor originating from the vascular endothelium. Morphological manifestations and immunohistochemical staining results are key to diagnosing EHE. Herein, we present a case of cutaneous involment in a recurrence of EHE. A 75-year-old woman presented with a month-long history of persistent erythematous plaque and pain in the left shoulder. Skin biopsy specimen revealed epithelioid tumor cells containing abundant eosinophilic cytoplasm. Immunohistochemical staining confirmed a recurrence of EHE involving the skin. Subsequently, recombinant human endostatin was administered. At the 10-day follow-up, the cutaneous plaque had improved, and the pain had resolved. When presenting as a local painful erythematous plaque, the possibility of skin involvement in a malignant tumor should be considered. Early diagnosis and early systemic therapy have an important impact on the overall survival of patients with EHE.
上皮样血管瘤（EHE）是一种罕见的起源于血管内皮的恶性肿瘤。形态学表现和免疫组化染色结果是诊断EHE的关键。在此，我们报告一例EHE复发累及皮肤的病例。一名75岁女性，有持续一个月的左肩持续性红斑斑块及疼痛病史。皮肤活检标本显示上皮样肿瘤细胞含有丰富的嗜酸性细胞质。免疫组化染色证实EHE复发累及皮肤。随后给予重组人内皮抑素治疗。在10天的随访中，皮肤斑块有所改善，疼痛缓解。当表现为局部疼痛性红斑斑块时，应考虑恶性肿瘤累及皮肤的可能性。早期诊断和早期全身治疗对EHE患者的总生存有重要影响。
