Cohen M R, Cohen R M, Pickar D, Kreger D, McLellan C, Murphy D L
Neuropeptides. 1985 Jul;6(4):373-80. doi: 10.1016/0143-4179(85)90010-1.
Utilizing a double-blind crossover design, the hormonal effects of high dose, 2 mg/kg, were compared to low dose, 0.4 mg (approx. 5 micrograms/kg), naloxone administration in physically healthy humans. A significant naloxone dose effect on plasma cortisol levels was found (p less than 0.001), but no significant effect on plasma or serum levels of prolactin, follicle stimulating hormone, luteinizing hormone, norepinephrine or epinephrine. These results confirm involvement of the endogenous opioid system (EOS) in the tonic regulation of the hypothalamicpituitary-adrenal axis, but fail to find evidence of EOS involvement in the regulation of adrenal medullary function or the gonadotrophic axis in man. The results are however consistent with a continuing action of naloxone as an EOS antagonist even at high doses in man.
采用双盲交叉设计，在身体健康的人类受试者中，比较了高剂量（2毫克/千克）与低剂量（0.4毫克，约5微克/千克）纳洛酮给药的激素效应。发现纳洛酮剂量对血浆皮质醇水平有显著影响（p<0.001），但对血浆或血清中的催乳素、促卵泡激素、促黄体生成素、去甲肾上腺素或肾上腺素水平无显著影响。这些结果证实内源性阿片系统（EOS）参与下丘脑-垂体-肾上腺轴的紧张性调节，但未发现EOS参与人类肾上腺髓质功能或促性腺轴调节的证据。然而，这些结果与纳洛酮即使在高剂量时在人体内仍作为EOS拮抗剂持续发挥作用是一致的。
