Derfoufi Jihane, Rezzoug Fatima, El Jarroudi Meryem, Nassira Karich, Al Jarroudi Ouissam, Brahmi Sami Aziz, Afqir Said
Medical Oncology, Mohammed VI University Hospital, Faculty of Medicine and Pharmacy, Mohamed I University, Oujda, MAR.
Pathology, Mohammed VI University Hospital, Oujda, MAR.
Cureus. 2024 Aug 22;16(8):e67469. doi: 10.7759/cureus.67469. eCollection 2024 Aug.
The metastasis of a primary lung tumor to the mouth cavity is a rare occurrence. In addition, the occurrence of neuroendocrine bronchial carcinoma with large cells is uncommon. When metastases are not possible to surgically remove, the conventional treatment for large-cell neuroendocrine tumors (LCNET) is still used. The etiology of these metastases remains inadequately comprehended, rendering their administration very intricate. The oncologist at this institution must possess a comprehensive comprehension of how to effectively oversee the patient's quality of life to guarantee the uninterrupted progression of therapy. This paper is a case study of a 51-year-old male patient who was hospitalized due to a severe dry cough and dysphonia that began two months prior to seeking medical consultation. Gingival hyperplasia was diagnosed during a clinical examination. The diagnosis of LCNET (carcinoma of the lung) was determined after a thorough etiological investigation utilizing gingival samples and pulmonary tissue. The objective of this study was to provide a description of our case, conduct an analysis of the response to therapy, and make a contribution to the current body of research. The purpose was to encourage more investigation into this type of metastasis, aiming to get a deeper comprehension of the mechanisms behind the metastatic spread and assess its predictive significance in future instances.
原发性肺肿瘤转移至口腔是一种罕见的情况。此外,大细胞神经内分泌支气管癌的发生也不常见。当转移灶无法通过手术切除时,仍采用大细胞神经内分泌肿瘤(LCNET)的传统治疗方法。这些转移灶的病因仍未得到充分理解,导致其治疗非常复杂。该机构的肿瘤学家必须全面了解如何有效管理患者的生活质量,以确保治疗的持续进行。本文是一例51岁男性患者的病例研究,该患者因严重干咳和声音嘶哑在就诊前两个月开始出现症状而住院。临床检查时诊断为牙龈增生。利用牙龈样本和肺组织进行全面病因调查后,确诊为LCNET(肺癌)。本研究的目的是描述我们的病例,分析治疗反应,并为当前的研究做出贡献。目的是鼓励对这种转移类型进行更多研究,旨在更深入地了解转移扩散背后的机制,并评估其在未来病例中的预测意义。