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肺大细胞神经内分泌癌罕见转移至颊腭部区域

Uncommon Metastasis of a Large-Cell Neuroendocrine Carcinoma From the Lungs to the Buccal Palatal Region.

作者信息

Derfoufi Jihane, Rezzoug Fatima, El Jarroudi Meryem, Nassira Karich, Al Jarroudi Ouissam, Brahmi Sami Aziz, Afqir Said

机构信息

Medical Oncology, Mohammed VI University Hospital, Faculty of Medicine and Pharmacy, Mohamed I University, Oujda, MAR.

Pathology, Mohammed VI University Hospital, Oujda, MAR.

出版信息

Cureus. 2024 Aug 22;16(8):e67469. doi: 10.7759/cureus.67469. eCollection 2024 Aug.

Abstract

The metastasis of a primary lung tumor to the mouth cavity is a rare occurrence. In addition, the occurrence of neuroendocrine bronchial carcinoma with large cells is uncommon. When metastases are not possible to surgically remove, the conventional treatment for large-cell neuroendocrine tumors (LCNET) is still used. The etiology of these metastases remains inadequately comprehended, rendering their administration very intricate. The oncologist at this institution must possess a comprehensive comprehension of how to effectively oversee the patient's quality of life to guarantee the uninterrupted progression of therapy. This paper is a case study of a 51-year-old male patient who was hospitalized due to a severe dry cough and dysphonia that began two months prior to seeking medical consultation. Gingival hyperplasia was diagnosed during a clinical examination. The diagnosis of LCNET (carcinoma of the lung) was determined after a thorough etiological investigation utilizing gingival samples and pulmonary tissue. The objective of this study was to provide a description of our case, conduct an analysis of the response to therapy, and make a contribution to the current body of research. The purpose was to encourage more investigation into this type of metastasis, aiming to get a deeper comprehension of the mechanisms behind the metastatic spread and assess its predictive significance in future instances.

摘要

原发性肺肿瘤转移至口腔是一种罕见的情况。此外,大细胞神经内分泌支气管癌的发生也不常见。当转移灶无法通过手术切除时,仍采用大细胞神经内分泌肿瘤(LCNET)的传统治疗方法。这些转移灶的病因仍未得到充分理解,导致其治疗非常复杂。该机构的肿瘤学家必须全面了解如何有效管理患者的生活质量,以确保治疗的持续进行。本文是一例51岁男性患者的病例研究,该患者因严重干咳和声音嘶哑在就诊前两个月开始出现症状而住院。临床检查时诊断为牙龈增生。利用牙龈样本和肺组织进行全面病因调查后,确诊为LCNET(肺癌)。本研究的目的是描述我们的病例,分析治疗反应,并为当前的研究做出贡献。目的是鼓励对这种转移类型进行更多研究,旨在更深入地了解转移扩散背后的机制,并评估其在未来病例中的预测意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2555/11415842/78fbc61d9a38/cureus-0016-00000067469-i01.jpg

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