Maj M, Arena F, Lovero N, Pirozzi R, Kemali D
Pharmacopsychiatry. 1985 Sep;18(5):309-13. doi: 10.1055/s-2007-1017387.
The relationship of some clinical, personality and biological variables to the outcome of lithium prophylaxis was investigated in two patient samples fulfilling, respectively, the DSM III definitions of "major depression, recurrent" and "bipolar disorder". In major depressives, the presence of psychomotor retardation and melancholia during the index episode was associated with a favorable response to treatment, whereas the presence of mood-incongruent psychotic features during the same episode, a high score on the "anxiety" and "phobic" subscales of the Middlesex Hospital Questionnaire and a high score on the "neuroticism" subscale of the Eysenck Personality Questionnaire were related to a poor response. These findings are discussed in the light of the heterogeneity of DSM III major depression and of the reported common occurrence of an "anxiety-phobic" personality profile in unipolar depressives. In bipolar patients, a family history of bipolar affective illness and a high lithium ratio were associated with a good response to treatment, and the presence of the HLA-A3 antigen with an unfavorable response. These findings seem to support a role of pharmacogenetic factors in conditioning response to lithium prophylaxis.
在分别符合“复发性重度抑郁症”和“双相情感障碍”的DSM III定义的两个患者样本中，研究了一些临床、人格和生物学变量与锂盐预防性治疗结果之间的关系。在重度抑郁症患者中，首次发作时存在精神运动性迟缓及抑郁情绪与对治疗的良好反应相关，而在同一发作期间存在与心境不符的精神病性特征、在米德尔塞克斯医院问卷的“焦虑”和“恐惧”分量表上得分高以及在艾森克人格问卷的“神经质”分量表上得分高则与反应不佳相关。鉴于DSM III重度抑郁症的异质性以及报道的单相抑郁症患者中常见的“焦虑 - 恐惧”人格特征，对这些发现进行了讨论。在双相情感障碍患者中，双相情感性疾病家族史和高锂比值与对治疗的良好反应相关，而存在HLA - A3抗原则与不良反应相关。这些发现似乎支持了药物遗传学因素在调节对锂盐预防性治疗反应中的作用。
