Hefei Ion Medical Center, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Department of Pharmacy, Affiliated Psychological Hospital of Anhui Medical University, Anhui Hefei, China.
Geriatr Gerontol Int. 2024 Nov;24(11):1210-1217. doi: 10.1111/ggi.14981. Epub 2024 Sep 23.
This study aims to explore the association between declining lung function and depression in middle-aged and older adults, with a special focus on the mediating role of cognitive function.
This study utilizes self-reported and physical examination data from 5345 individuals participating in the 2015 cycle of the China Health and Retirement Longitudinal Study (CHARLS) to explore the role of cognitive function changes in mediating the effects of diminished lung function on depression among middle-aged and older adults.
Multivariate linear regression analysis revealed a positive correlation between pulmonary and cognitive functions (β = 0.003, 95% CI: 0.002∼0.003, P < 0.01) and a negative correlation between cognitive function and depression (β = -0.279, 95% CI: -0.330-0.228, P < 0.01). Cognitive function plays a mediating role in linking pulmonary function with depression, exhibiting a mediation effect of -0.0007 and a total effect of -0.0046, wherein the mediation effect contributes to 15.22% of the total effect. For females, the mediating effect of cognitive function was stronger (β = -0.0013, 95% CI: -0.0018∼-0.0008, P < 0.01) than it was for males (β = -0.0006, 95% CI: -0.0009∼-0.0003, P < 0.01).
The study underscores the importance of monitoring lung and cognitive functions as interconnected factors contributing to the mental health of middle-aged and older adults. It suggests that interventions aimed at improving pulmonary health and cognitive function may help mitigate depressive symptoms among middle-aged and older adults. Further research is warranted to validate these findings across diverse cultural and demographic settings. Geriatr Gerontol Int 2024; 24: 1210-1217.
本研究旨在探讨中年及老年人肺功能下降与抑郁之间的关联，并特别关注认知功能的中介作用。
本研究利用 5345 名参与 2015 年中国健康与退休纵向研究（CHARLS）的个体的自我报告和体检数据，探讨认知功能变化在中年及老年人中，肺功能下降对抑郁影响的中介作用。
多变量线性回归分析显示，肺功能和认知功能之间呈正相关（β=0.003，95%CI：0.002∼0.003，P<0.01），认知功能与抑郁之间呈负相关（β=-0.279，95%CI：-0.330-0.228，P<0.01）。认知功能在肺功能与抑郁之间起中介作用，中介效应为-0.0007，总效应为-0.0046，其中中介效应占总效应的 15.22%。对于女性，认知功能的中介效应更强（β=-0.0013，95%CI：-0.0018∼-0.0008，P<0.01），而对于男性，认知功能的中介效应较弱（β=-0.0006，95%CI：-0.0009∼-0.0003，P<0.01）。
本研究强调了监测肺功能和认知功能作为相互关联的因素对中年及老年人心理健康的重要性。研究表明，旨在改善肺健康和认知功能的干预措施可能有助于减轻中年及老年人的抑郁症状。需要进一步的研究来验证这些发现在不同文化和人口统计学背景下的适用性。
老年医学与保健 2024；24：1210-1217
