Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Professor Gama Pinto, 1649-003, Lisboa, Portugal.
Instituto de Biofísica e Engenharia Biomédica (IBEB), Faculdade de Ciências, Universidade de Lisboa, Campo Grande, 1749-016, Lisboa, Portugal.
Ther Deliv. 2024;15(10):781-799. doi: 10.1080/20415990.2024.2395249. Epub 2024 Sep 24.
Superficial cancers typically refer to cancers confined to the surface layers of tissue. Low-targeting therapies or side effects prompt exploration of novel therapeutic approaches. Gold nanoparticles (AuNPs), due to their unique optical properties, serve as effective photosensitizers, enabling tumor ablation through photothermal therapy (PTT). PTT induced by AuNPs can be achieved through light sources externally applied to the skin. Near-infrared radiation is the main light candidate due to its deep tissue penetration capability. This review explores recent advancements in AuNP-based PTT for superficial cancers, specifically breast, head and neck, thyroid, bladder and prostate cancers. Additionally, challenges and future directions in utilizing AuNPs for cancer treatment are discussed, emphasizing the importance of balancing efficacy with safety in clinical applications.
表浅癌症通常是指局限于组织表层的癌症。低靶向性治疗或副作用促使人们探索新的治疗方法。由于其独特的光学特性,金纳米粒子(AuNPs)可用作有效的光敏剂,通过光热疗法(PTT)实现肿瘤消融。AuNPs 诱导的 PTT 可通过施加于皮肤的外部光源实现。近红外辐射是主要的候选光源,因为它具有深层组织穿透能力。本综述探讨了基于 AuNP 的 PTT 在表浅癌症(特别是乳腺癌、头颈部癌、甲状腺癌、膀胱癌和前列腺癌)中的最新进展。此外,还讨论了利用 AuNPs 进行癌症治疗的挑战和未来方向,强调在临床应用中平衡疗效和安全性的重要性。