Amsterdam J D, Winokur A, Dyson W, Herzog S, Gonzalez F, Rott R, Koprowski H
Arch Gen Psychiatry. 1985 Nov;42(11):1093-6. doi: 10.1001/archpsyc.1985.01790340077011.
Borna disease virus is a unique neurotropic agent that appears to have a predilection for the limbic area of the brain. In some animal species, it can produce a behavioral syndrome characterized by aggressive and passive phases. This syndrome has suggested an analogy to certain human affective disorders. In this preliminary study, we examined the possible involvement of Borna disease virus in the etiology of human mood disorders by assaying for virus-specific antibodies in 265 patients with unipolar or bipolar depression and 105 normal, healthy volunteers. Twelve patients (4.5%) and none of the healthy controls demonstrated this antibody in their serum samples. It will be necessary to replicate and extend these intriguing preliminary results to determine if Borna disease virus is possibly involved in the pathogenesis of affective disorders in humans.
博尔纳病病毒是一种独特的嗜神经因子，似乎对大脑边缘区域有偏好。在某些动物物种中，它可产生一种以攻击和被动阶段为特征的行为综合征。这种综合征已提示与某些人类情感障碍存在相似之处。在这项初步研究中，我们通过检测265例单相或双相抑郁症患者及105名正常健康志愿者的病毒特异性抗体，来研究博尔纳病病毒在人类情绪障碍病因学中可能的作用。12例患者（4.5%）的血清样本中检测到了这种抗体，而健康对照组均未检测到。有必要重复并扩展这些有趣的初步结果，以确定博尔纳病病毒是否可能参与人类情感障碍的发病机制。
