Rott R, Herzog S, Fleischer B, Winokur A, Amsterdam J, Dyson W, Koprowski H
Science. 1985 May 10;228(4700):755-6. doi: 10.1126/science.3922055.
Borna disease virus causes a rare meningoencephalitis in horses and sheep and has been shown to produce behavioral effects in some species. The possibility that the Borna virus is associated with mental disorders in humans was evaluated by examining serum samples from 979 psychiatric patients and 200 normal volunteers for the presence of Borna virus-specific antibodies. Antibodies were detected by the indirect immunofluorescence focus assay. Antibodies to the virus were demonstrated in 16 of the patients but none of the normal volunteers. The patients with the positive serum samples were characterized by having histories of affective disorders, particularly of a cyclic nature. Further studies are needed to define the possible involvement of Borna virus in human psychiatric disturbances.
博尔纳病病毒可在马和绵羊中引发一种罕见的脑膜脑炎，并且已证实在某些物种中会产生行为影响。通过检测979名精神科患者和200名正常志愿者的血清样本中是否存在博尔纳病毒特异性抗体，来评估博尔纳病毒与人类精神障碍相关的可能性。通过间接免疫荧光聚焦试验检测抗体。在16名患者中检测到了该病毒的抗体，而正常志愿者中未检测到。血清样本呈阳性的患者的特点是有情感障碍病史，尤其是周期性情感障碍病史。需要进一步研究来确定博尔纳病毒在人类精神障碍中可能所起的作用。
