Lu Jing, Yu Chaosheng, Du Kun, Chen Shuaijun, Huang Shuixian
School of Gongli Hospital Medical Technology, University of Shanghai for Science and Technology, Shanghai, China.
Department of Otorhinolaryngology-Head and Neck Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Colloids Surf B Biointerfaces. 2025 Jan;245:114252. doi: 10.1016/j.colsurfb.2024.114252. Epub 2024 Sep 16.
Rapid advances in nanotechnology are paving the way for innovative breakthroughs in overcoming the current limitations in the clinical treatment of cancer and other prevalent diseases plaguing mankind. Magnetic nanoparticles composed of iron oxide (FeO) are a novel class of nanoparticles that are receiving increasing attention in the field of cancer therapy. To address the inherent limitations, bare FeO can be functionalized, polymerized, assembled, or combined with other functional materials to produce a range of smart nanoplatforms suitable for tumor therapy. In this paper, we present a unique multifunctional therapeutic nanoplatform centered on aldehyde-oxidized sodium alginate-stabilized iron oxide nanoparticles (NPs) designed for T-weighted magnetic resonance (MR) imaging. Sodium alginate oxide and ferric oxide nanoparticles were prepared respectively, and the two particles were mixed in a certain molar ratio to form a complex, which was coupled to target polypeptide GE11 by Schiff base reaction, and finally supported by cisplatin through coordination complexation. The prepared magnetic nanoparticles (hereinafter referred to as GE11-CDDP-ASA@FeO) have an average diameter of 152.9 nm, and have good colloidal stability and cytocompatibility. The distinctive structure and composition of GE11-CDDP-ASA@FeO contribute to its excellent MRI imaging performance, positioning it as a nano platform suitable for enhancing the efficacy of combination therapy in tumor treatment. This is of great significance for translational nanomedicine applications.
纳米技术的飞速发展正在为克服当前癌症及其他困扰人类的常见疾病临床治疗中的局限性带来创新性突破铺平道路。由氧化铁（FeO）组成的磁性纳米颗粒是一类新型纳米颗粒，在癌症治疗领域正受到越来越多的关注。为解决其固有局限性，裸露的FeO可进行功能化、聚合、组装或与其他功能材料结合，以制备一系列适用于肿瘤治疗的智能纳米平台。在本文中，我们展示了一种独特的多功能治疗性纳米平台，该平台以醛氧化海藻酸钠稳定的氧化铁纳米颗粒（NPs）为核心，用于T加权磁共振（MR）成像。分别制备了氧化海藻酸钠和氧化铁纳米颗粒，将两种颗粒按一定摩尔比混合形成复合物，通过席夫碱反应将其与靶向多肽GE11偶联，最后通过配位络合负载顺铂。制备的磁性纳米颗粒（以下简称GE11-CDDP-ASA@FeO）平均直径为152.9 nm，具有良好的胶体稳定性和细胞相容性。GE11-CDDP-ASA@FeO独特的结构和组成有助于其优异的MRI成像性能，使其成为适合增强肿瘤治疗联合疗法疗效的纳米平台。这对转化纳米医学应用具有重要意义。
