Wang Xiu-Zhen, Chen Yue, Cao Xiao-Min, Li Ru-Yi, Chen Wei-Yan, Li Yue, Guo Dong-Sheng
College of Chemistry, Nankai University, 94 Weijin Road, Tianjin, 300071, China.
College of Chemistry, Key Laboratory of Functional Polymer Materials (Ministry of Education), State Key Laboratory of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, Tianjin, 300071, China.
Angew Chem Int Ed Engl. 2025 Jan 2;64(1):e202413115. doi: 10.1002/anie.202413115. Epub 2024 Nov 2.
Two-dimensional conjugated metal-organic frameworks (2D c-MOFs) have shown great promise in various electrochemical applications due to their intrinsic electrical conductivity. A large pore aperture is a favorable feature of this type of material because it facilitates the mass transport of chemical species and electrolytes. In this work, we propose a ligand insertion strategy in which a linear ligand is inserted into the linkage between multitopic ligands, extending the metal ion into a linear unit of -M-ligand-M-, for the construction of 2D c-MOFs with large pore apertures, utilizing only small ligands. As a proof-of-concept trial of this strategy, a 2D c-MOF with mesopores of 3.2 nm was synthesized using commercially available ligands hexahydrotriphenylene and 2,5-dihydroxybenzoquinone. The facilitation of the diffusion of redox species by the large pore size of this MOF was demonstrated through a series of probes. With this feature, it showed superior performance in the electrochemical analysis of a variety of biological species.
二维共轭金属有机框架材料（2D c-MOFs）因其固有的导电性，在各种电化学应用中展现出了巨大的潜力。大孔径是这类材料的一个有利特性，因为它有助于化学物质和电解质的质量传输。在这项工作中，我们提出了一种配体插入策略，即将线性配体插入多齿配体之间的连接中，将金属离子扩展为-M-配体-M-的线性单元，用于构建具有大孔径的2D c-MOFs，且仅使用小分子配体。作为该策略的概念验证试验，使用市售配体六氢三亚苯和2,5-二羟基苯醌合成了一种具有3.2 nm中孔的2D c-MOF。通过一系列探针证明了该MOF的大孔径促进了氧化还原物种的扩散。基于这一特性，它在多种生物物种的电化学分析中表现出优异的性能。
