在老年人中，α-klotho 和 FGF-23 的血浓度与骨密度无相关性。
Blood concentrations of α-Klotho and FGF-23 exhibit no correlation with bone mineral density in elderly individuals.
机构信息
Discipline of Geriatrics, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Discipline of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
出版信息
Einstein (Sao Paulo). 2024 Sep 20;22:eAO0412. doi: 10.31744/einstein_journal/2024AO0412. eCollection 2024.
OBJECTIVE
To investigating the relationship between α-Klotho and FGF-23 with bone biochemical markers and bone density findings in extremely aged individuals.
METHODS
A total of 55 individuals with a mean age of 85.6 years were subjected to clinical, biochemical, and bone mineral density analyses and the enzyme-linked immunosorbent assay-based detection of α-Klotho and FGF-23. The mean, standard deviation, median, and interquartile ranges of the sample values were determined, and Spearman's test for association assessments was used for statistical analysis.
RESULTS
The study participants expressed median FGF-23 and α-Klotho levels of 69.81 RU/mL (51.43 RU/mL) and 733.43 pg/mL (360.83 pg/mL), respectively. The majority of the participants possessed osteopenia (54.5%) and a vitamin D deficiency (57%). The 25-hydroxyvitamin D concentrations ranged between 7.1 and 47.5ng/mL, with a median of 18.1ng/mL.
CONCLUSION
No substantial associations were discovered between α-Klotho and FGF-23 levels and bone density in the study participants.
目的
探讨极度高龄个体中α-Klotho 与 FGF-23 与骨生化标志物和骨密度之间的关系。
方法
共纳入 55 名平均年龄为 85.6 岁的个体，进行临床、生化和骨密度分析，并采用基于酶联免疫吸附试验的α-Klotho 和 FGF-23 检测。确定样本值的平均值、标准差、中位数和四分位间距，并进行 Spearman 相关性评估的统计分析。
结果
研究参与者的 FGF-23 和 α-Klotho 中位数水平分别为 69.81 RU/mL（51.43 RU/mL）和 733.43 pg/mL（360.83 pg/mL）。大多数参与者存在骨量减少（54.5%）和维生素 D 缺乏（57%）。25-羟维生素 D 浓度在 7.1 至 47.5ng/mL 之间，中位数为 18.1ng/mL。
结论
在研究参与者中，α-Klotho 和 FGF-23 水平与骨密度之间未发现显著关联。
Zotero 插件