Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Escola de Artes, Ciências e Humanidades, Universidade de São Paulo, São Paulo, SP, Brazil.
Einstein (Sao Paulo). 2021 Aug 2;19:eAO5925. doi: 10.31744/einstein_journal/2021AO5925. eCollection 2021.
To examine the association of between serum fibroblast growth factor 23 and the functional capacity among independent individuals, aged 80 or older.
The functional capacity of 144 elderly was assessed by Instrumental Activities of Daily Living, cognitive tests, handgrip strength and the timed ability to rise from a chair and sit down five times. Fibroblast growth factor 23 was measured using an ELISA assay.
Participants in the lowest fibroblast growth factor 23 tertile had the highest mean±standard deviation estimated glomerular filtration rate, the highest mean hemoglobin level, the lowest average number of diseases and the lowest number of medications used. In participants with the estimated glomerular filtration rate >45mL/minute/1.73m2, mean fibroblast growth factor 23 level was higher in those with 25(OH) vitamin D <20ng/mL than in those with 25(OH) vitamin D ≥20ng/mL (75.6RU/mL±42.8 versus 68.5RU/mL±41.7; p<0.001). There was an increase in the mean serum cystatin C (from 1.3mg/mL±0.3 to 1.5mg/mL±0.3 to 1.7mg/mL±0.4) as function of higher fibroblast growth factor 23 tertile (p<0.001). Fibroblast growth factor 23 levels were not significantly associated with capacity in physical or cognitive tests.
In independent community-dwelling elderly, aged ≥80 years, fibroblast growth factor 23 was associated with aged-related comorbidities and renal function but not with functional capacity.
研究血清成纤维细胞生长因子 23（fibroblast growth factor 23，FGF23）与 80 岁及以上独立个体功能能力之间的关系。
采用工具性日常生活活动能力、认知测试、握力和定时从椅子上站起来并坐下 5 次的能力评估 144 名老年人的功能能力。采用酶联免疫吸附试验（ELISA）测定 FGF23。
在 FGF23 最低三分位的参与者中，估算肾小球滤过率（estimated glomerular filtration rate，eGFR）的平均标准差最高，血红蛋白水平最高，平均患病数量最低，使用药物数量最少。在 eGFR>45mL/min/1.73m2 的参与者中，25 羟维生素 D<20ng/mL 的参与者的平均 FGF23 水平高于 25 羟维生素 D≥20ng/mL 的参与者（75.6RU/mL±42.8 比 68.5RU/mL±41.7；p<0.001）。随着 FGF23 三分位值的升高，血清胱抑素 C 的平均值（从 1.3mg/mL±0.3 升高至 1.5mg/mL±0.3 再升高至 1.7mg/mL±0.4）也升高（p<0.001）。FGF23 水平与体力或认知测试的能力无显著相关性。
在 80 岁及以上独立的社区居住老年人中，FGF23 与与年龄相关的合并症和肾功能相关，但与功能能力无关。
