Kennedy Chris J, Kearns Jaclyn C, Geraci Joseph C, Gildea Sarah M, Hwang Irving H, King Andrew J, Liu Howard, Luedtke Alex, Marx Brian P, Papini Santiago, Petukhova Maria V, Sampson Nancy A, Smoller Jordan W, Wolock Charles J, Zainal Nur Hani, Stein Murray B, Ursano Robert J, Wagner James R, Kessler Ronald C
Department of Psychiatry, Massachusetts General Hospital, Boston.
National Center for PTSD, VA Boston Healthcare System, Boston, Massachusetts.
JAMA Psychiatry. 2024 Dec 1;81(12):1215-1224. doi: 10.1001/jamapsychiatry.2024.2744.
The suicide rate of military servicemembers increases sharply after returning to civilian life. Identifying high-risk servicemembers before they leave service could help target preventive interventions.
To develop a model based on administrative data for regular US Army soldiers that can predict suicides 1 to 120 months after leaving active service.
DESIGN, SETTING, AND PARTICIPANTS: In this prognostic study, a consolidated administrative database was created for all regular US Army soldiers who left service from 2010 through 2019. Machine learning models were trained to predict suicides over the next 1 to 120 months in a random 70% training sample. Validation was implemented in the remaining 30%. Data were analyzed from March 2023 through March 2024.
The outcome was suicide in the National Death Index. Predictors came from administrative records available before leaving service on sociodemographics, Army career characteristics, psychopathologic risk factors, indicators of physical health, social networks and supports, and stressors.
Of the 800 579 soldiers in the cohort (84.9% male; median [IQR] age at discharge, 26 [23-33] years), 2084 suicides had occurred as of December 31, 2019 (51.6 per 100 000 person-years). A lasso model assuming consistent slopes over time discriminated as well over all but the shortest risk horizons as more complex stacked generalization ensemble machine learning models. Test sample area under the receiver operating characteristic curve ranged from 0.87 (SE = 0.06) for suicides in the first month after leaving service to 0.72 (SE = 0.003) for suicides over 120 months. The 10% of soldiers with highest predicted risk accounted for between 30.7% (SE = 1.8) and 46.6% (SE = 6.6) of all suicides across horizons. Calibration was for the most part better for the lasso model than the super learner model (both estimated over 120-month horizons.) Net benefit of a model-informed prevention strategy was positive compared with intervene-with-all or intervene-with-none strategies over a range of plausible intervention thresholds. Sociodemographics, Army career characteristics, and psychopathologic risk factors were the most important classes of predictors.
These results demonstrated that a model based on administrative variables available at the time of leaving active Army service can predict suicides with meaningful accuracy over the subsequent decade. However, final determination of cost-effectiveness would require information beyond the scope of this report about intervention content, costs, and effects over relevant horizons in relation to the monetary value placed on preventing suicides.
军人退役后回归平民生活,自杀率会急剧上升。在军人退役前识别出高风险个体,有助于针对性地进行预防干预。
基于美国陆军正规士兵的行政数据开发一个模型,该模型能够预测他们退役后1至120个月内的自杀情况。
设计、设置和参与者:在这项预后研究中,为2010年至2019年退役的所有美国陆军正规士兵创建了一个综合行政数据库。在随机抽取的70%的训练样本中,训练机器学习模型以预测未来1至120个月内的自杀情况。在其余30%的样本中进行验证。数据于2023年3月至2024年3月进行分析。
结局为国家死亡指数中的自杀情况。预测因素来自退役前可获取的行政记录,包括社会人口统计学、陆军服役经历特征、心理病理风险因素、身体健康指标、社交网络与支持以及压力源。
该队列中有800579名士兵(84.9%为男性;退役时的年龄中位数[四分位间距]为26[23 - 33]岁),截至2019年12月31日,共发生2084起自杀事件(每10万人年51.6例)。与更复杂的堆叠泛化集成机器学习模型相比,假设随时间斜率一致的套索模型在除最短风险期外的所有风险期内都具有良好的区分能力。受试者工作特征曲线下的测试样本面积范围从退役后第一个月自杀的0.87(标准误 = 0.06)到120个月以上自杀的0.72(标准误 = 0.003)。预测风险最高的10%的士兵在各个风险期内占所有自杀事件的30.7%(标准误 = 1.8)至46.6%(标准误 = 6.6)。在大多数情况下,套索模型的校准效果优于超级学习器模型(两者均在120个月的风险期内进行估计)。与在一系列合理干预阈值下的全面干预或不干预策略相比,基于模型的预防策略的净效益为正。社会人口统计学、陆军服役经历特征和心理病理风险因素是最重要的预测因素类别。
这些结果表明,基于陆军现役退役时可用行政变量的模型能够在随后十年内以有意义的准确度预测自杀情况。然而,最终确定成本效益需要超出本报告范围的信息,即关于干预内容、成本以及在相关时间段内与预防自杀货币价值相关的效果信息。