Tamaki N, Fujimoto S, Mizutani N, Mizota C
FEBS Lett. 1985 Oct 21;191(1):113-6. doi: 10.1016/0014-5793(85)81004-8.
When 6-azauracil was subcutaneously injected, beta-aminoisobutyric acid and beta-alanine contents were increased 22 and 61-fold, respectively, in rat liver. Incorporation of [methyl-14C]thymine into beta-aminoisobutyric acid was increased to 42-fold by 6-azauracil treatment. The absolute configuration of this amino acid was proved to be the (R)-form by means of a gas-chromatographic technique. 6-Azauracil inhibited beta-alanine-pyruvate aminotransferase activity with an I50 of approx. 2.5 mM.
当皮下注射6-氮杂尿嘧啶时，大鼠肝脏中β-氨基异丁酸和β-丙氨酸的含量分别增加了22倍和61倍。经6-氮杂尿嘧啶处理后，[甲基-14C]胸腺嘧啶掺入β-氨基异丁酸的量增加到42倍。通过气相色谱技术证明该氨基酸的绝对构型为(R)-型。6-氮杂尿嘧啶抑制β-丙氨酸-丙酮酸转氨酶活性，其半数抑制浓度约为2.5 mM。
