Meech P R, Hardie I R, Hartley L C, Strong R W, Clunie G J
Aust N Z J Surg. 1979 Dec;49(6):621-5. doi: 10.1111/j.1445-2197.1979.tb06474.x.
Gastrointestinal complications occurred in 19 of 290 recipients (6.6%) of the 325 cadaveric renal allografts undertaken between September 1969 and December 1978. The mortality was 42.1%. Upper gastrointestinal complications, principally haemorrhage, occurred in 12 patients (4.1%), 11 of whom were males, usually within four months of transplantation, and often associated with acute rejection and its treatment. Surgery was required in five patients. The overall mortality was 16.7%. Colonic complications occurred in five patients (1.7%), four of whom died, the absence of specific signs having led to a significant delay in diagnosis. One patient died from abdominal vascular disease, and one from carcinoma of the gallbladder. To decrease the high morbidity and mortality, both medical and appropriate surgical prophylaxis for peptic ulceration and diverticular disease are necessary, as is an awareness of the transplant recipient's propensity to develop a gastrointestinal complication at any time, up to years after transplantation. Early recognition and treatment of such complications are essential.
在1969年9月至1978年12月间进行的325例尸体肾移植中，290例受者中有19例（6.6%）发生了胃肠道并发症。死亡率为42.1%。上消化道并发症主要为出血，发生在12例患者（4.1%）中，其中11例为男性，通常在移植后四个月内发生，且常与急性排斥反应及其治疗相关。5例患者需要手术治疗。总体死亡率为16.7%。结肠并发症发生在5例患者（1.7%）中，其中4例死亡，由于缺乏特异性体征导致诊断明显延迟。1例患者死于腹部血管疾病，1例死于胆囊癌。为降低高发病率和死亡率，对消化性溃疡和憩室病进行药物及适当的手术预防是必要的，同时还需意识到移植受者在移植后数年随时都有发生胃肠道并发症的倾向。尽早识别和治疗此类并发症至关重要。
