Department of Dermatology, Zealand University Hospital, Roskilde, Denmark.
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Mycoses. 2024 Sep;67(9):e13802. doi: 10.1111/myc.13802.
Tinea pedis is one of the most prevalent superficial fungal infections. Initial antifungal treatment is often acquired over-the-counter (OTC) without previous consultation with a physician.
Lately, increasing antifungal terbinafine resistance has been documented in Denmark and globally and it is therefore of interest to assess how Danish pharmacies advise customers with tinea pedis.
One hundred Danish pharmacies were randomly selected and an employee interviewed from each. A structured question guide was followed, with the possibility to add further comments.
Interviews of 94 pharmacies were conducted. Six pharmacies never replied. Terbinafine as standard dose or cutaneous solution terbinafine one time application (Lamisil Once (R)) were recommended by 99% of the pharmacy employees as first-line treatment. The customer was advised to seek medical attention when tinea pedis was recurring (93%), or when treatment duration was > 2 weeks (77%). The majority (88%) of the pharmacy employees had no knowledge about antifungal resistance.
Only few pharmacy employees were aware of the current problem of antifungal resistance and the majority advised costumers to initiate treatment using OTC topical terbinafine. The problem of emerging antifungal resistance requires attention in order to provide customers with tinea pedis effective treatment and prevent further societal spread of resistance to antifungals.
足癣是最常见的浅部真菌感染之一。最初的抗真菌治疗通常是在没有事先咨询医生的情况下在药店购买非处方（OTC）药物进行的。
最近，丹麦和全球范围内记录到抗真菌药物特比萘芬的耐药性不断增加，因此，评估丹麦的药店如何为患有足癣的患者提供建议是很有必要的。
随机选择了 100 家丹麦药店，并对每家药店的一名员工进行了采访。采访遵循了一个结构化的问题指南，并允许添加进一步的评论。
对 94 家药店进行了采访。有 6 家药店从未回复。99%的药店员工推荐标准剂量的特比萘芬或特比萘芬皮肤溶液（一次应用，兰美抒一次（R））作为一线治疗药物。当足癣复发（93%）或治疗持续时间超过 2 周（77%）时，建议顾客寻求医疗帮助。大多数（88%）的药店员工对抗真菌耐药性一无所知。
只有少数药店员工意识到当前抗真菌耐药性的问题，并且大多数建议顾客使用 OTC 局部特比萘芬开始治疗。为了为患有足癣的患者提供有效的治疗，并防止抗真菌药物耐药性进一步在社会中传播，需要对抗真菌耐药性的出现问题引起关注。
