ATF6 通过调控 Wnt 通路促进结直肠癌的生长和干性。
ATF6 Promotes Colorectal Cancer Growth and Stemness by Regulating the Wnt Pathway.
机构信息
Department of Research Oncology, Genentech, Inc., South San Francisco, California.
Department of Computational Science, Genentech, Inc., South San Francisco, California.
出版信息
Cancer Res Commun. 2024 Oct 1;4(10):2734-2755. doi: 10.1158/2767-9764.CRC-24-0268.
Abstract
ATF6 intervention reduces colorectal cancer cell and organoid viability by interrupting dysregulated Wnt signaling, identifying a novel facilitator and potential therapeutic target in colorectal cancer.
摘要
ATF6 干预通过中断失调的 Wnt 信号减少结直肠癌细胞和类器官的活力，鉴定了结直肠癌的新型促进因子和潜在治疗靶点。
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