School of Veterinary Science, Palmerston North, New Zealand.
Animal Referral Centre (Central), Auckland, New Zealand.
J Vet Intern Med. 2024 Nov-Dec;38(6):2982-2993. doi: 10.1111/jvim.17203. Epub 2024 Sep 26.
The proportion of cats with hypertrophic cardiomyopathy (HCM) that lose systolic anterior motion of the mitral valve (SAM) in the long term is unknown.
HYPOTHESIS/OBJECTIVES: Cats with HCM will lose SAM in the long term. Loss of SAM will be associated with greater age, longer scan-interval, and altered left ventricular (LV) dimensions.
Sixty unsedated cats with HCM, not receiving beta blockers or pimobendan.
A retrospective cohort study from 2 referral centers. Cats were eligible if they had been diagnosed with HCM and had a repeat echocardiogram ≥1 year later. Clinical and echocardiographic data of the left heart variables were collected.
Thirty-eight cats had SAM at the initial scan. After a median follow-up time of 2.1 years (range: 1.0-5.9), 7 cats had lost SAM (18%) and 5 cats (23%) gained SAM. On follow-up, cats with SAM at the initial scan had a larger left atrium (P = .037), lower left atrial fractional shortening (P = .014), greater LV internal diameter in end-systole (P = .002), and lower LV fractional shortening (P < .001). Four cats with SAM developed congestive heart failure. There were no new cases of congestive heart failure or change in left heart variables in cats without SAM at the initial scan. The gain or loss of SAM was not associated with age or time between scans.
Similar proportions of cats gained or lost SAM. Cats with SAM at baseline had more evidence of disease progression than cats without SAM.
长期以来，患有肥厚型心肌病（HCM）的猫中二尖瓣前叶收缩期前向运动（SAM）丧失的比例尚不清楚。
假设/目的：患有 HCM 的猫将在长期内失去 SAM。SAM 的丧失与更大的年龄、更长的扫描间隔以及左心室（LV）尺寸的改变有关。
60 只未镇静的患有 HCM 的猫，未接受β受体阻滞剂或匹莫苯丹治疗。
来自 2 个转诊中心的回顾性队列研究。如果猫被诊断患有 HCM 且在≥1 年后进行了重复超声心动图检查，则符合入组条件。收集了左心变量的临床和超声心动图数据。
38 只猫在初次扫描时存在 SAM。中位随访时间为 2.1 年（范围：1.0-5.9 年）后，7 只猫（18%）失去了 SAM，5 只猫（23%）获得了 SAM。在随访时，初次扫描时存在 SAM 的猫的左心房更大（P = .037），左心房分数缩短率更低（P = .014），左心室收缩末期内径更大（P = .002），左心室分数缩短率更低（P < .001）。4 只 SAM 猫出现充血性心力衰竭。在初次扫描时无 SAM 的猫中，没有新的充血性心力衰竭病例或左心变量改变。SAM 的获得或丧失与年龄或两次扫描之间的时间无关。
有相似比例的猫获得或丧失了 SAM。与无 SAM 的猫相比，基线时存在 SAM 的猫有更多疾病进展的证据。
